Target
Prostacyclin receptor
Ligand
BDBM23955
Substrate
BDBM23954
Meas. Tech.
IP Receptor Filter Binding Assay and cAMP Assay
pH
7.4±n/a
Temperature
295.15±n/a K
IC50
561±6 nM
EC50
66±16 nM
Citation
 Brescia, MRRokosz, LLCole, AGStauffer, TMLehrach, JMAuld, DSHenderson, IWebb, ML Discovery and preliminary evaluation of 5-(4-phenylbenzyl)oxazole-4-carboxamides as prostacyclin receptor antagonists. Bioorg Med Chem Lett 17:1211-5 (2007) [PubMed]  Article 
Target
Name:
Prostacyclin receptor
Synonyms:
PGI receptor | PI2R_HUMAN | PRIPR | PTGIR | Prostacyclin (IP) Receptor | Prostacyclin receptor | Prostaglandin I | Prostaglandin I2 | Prostaglandin I2 receptor | Prostanoid IP receptor
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
40968.22
Organism:
Homo sapiens (Human)
Description:
The membranes prepared from human platelet were used in binding assay.
Residue:
386
Sequence:
MADSCRNLTYVRGSVGPATSTLMFVAGVVGNGLALGILSARRPARPSAFAVLVTGLAATDLLGTSFLSPAVFVAYARNSSLLGLARGGPALCDAFAFAMTFFGLASMLILFAMAVERCLALSHPYLYAQLDGPRCARLALPAIYAFCVLFCALPLLGLGQHQQYCPGSWCFLRMRWAQPGGAAFSLAYAGLVALLVAAIFLCNGSVTLSLCRMYRQQKRHQGSLGPRPRTGEDEVDHLILLALMTVVMAVCSLPLTIRCFTQAVAPDSSSEMGDLLAFRFYAFNPILDPWVFILFRKAVFQRLKLWVCCLCLGPAHGDSQTPLSQLASGRRDPRAPSAPVGKEGSCVPLSAWGEGQVEPLPPTQQSSGSAVGTSSKAEASVACSLC
  
Inhibitor
Name:
BDBM23955
Synonyms:
5-(4-phenylbenzyl)oxazole-4-carboxamide, 6b | N-benzyl-5-{[4-(3-acetamidophenyl)phenyl]methyl}-1,3-oxazole-4-carboxamide
Type:
Small organic molecule
Emp. Form.:
C26H23N3O3
Mol. Mass.:
425.4791
SMILES:
CC(=O)Nc1cccc(c1)-c1ccc(Cc2ocnc2C(=O)NCc2ccccc2)cc1
Structure:
Search PDB for entries with ligand similarity:
Substrate
Name:
BDBM23954
Synonyms:
5-[(2E,3aS,4R,5R,6aS)-5-hydroxy-4-[(1E,3S)-3-hydroxy-4-methyloct-1-en-6-yn-1-yl]-octahydropentalen-2-ylidene]pentanoic acid | CHEMBL494 | ILOPROST | Ventavis | [3H]-Iloprost
Type:
radiolabeled ligand
Emp. Form.:
C22H32O4
Mol. Mass.:
360.4871
SMILES:
[H][C@]12C[C@@H](O)[C@H](\C=C\[C@@H](O)C(C)CC#CC)[C@@]1([H])C\C(C2)=C\CCCC(O)=O
Structure:
Search PDB for entries with ligand similarity: