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TargetCytosol aminopeptidase
LigandBDBM23985
Substrate/CompetitorBDBM23972
Meas. Tech.Enzyme Inhibition Assay
pH8±n/a
Temperature303.15±n/a K
IC50>1000000±n/a nM
Citation Albrecht, SDefoin, ASalomon, ETarnus, CWetterholm, AHaeggström, JZ Synthesis and structure activity relationships of novel non-peptidic metallo-aminopeptidase inhibitors. Bioorg Med Chem14:7241-57 (2006) [PubMed]  Article
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Cytosol aminopeptidase
Name:Cytosol aminopeptidase
Synonyms:LAP | LAPc | Leucine Aminopeptidase | Leucyl aminopeptidase
Type:Homohexamer
Mol. Mass.:56288.28
Organism:Bos taurus (bovine)
Description:Bovine kidney LAPc was purchased from Sigma Chemical Co.
Residue:519
Sequence:
MFLLPLPAAARVAVRHLSVKRLWAPGPAAADMTKGLVLGIYSKEKEEDEPQFTSAGENFN
KLVSGKLREILNISGPPLKAGKTRTFYGLHEDFPSVVVVGLGKKTAGIDEQENWHEGKEN
IRAAVAAGCRQIQDLEIPSVEVDPCGDAQAAAEGAVLGLYEYDDLKQKRKVVVSAKLHGS
EDQEAWQRGVLFASGQNLARRLMETPANEMTPTKFAEIVEENLKSASIKTDVFIRPKSWI
EEQEMGSFLSVAKGSEEPPVFLEIHYKGSPNASEPPLVFVGKGITFDSGGISIKAAANMD
LMRADMGGAATICSAIVSAAKLDLPINIVGLAPLCENMPSGKANKPGDVVRARNGKTIQV
DNTDAEGRLILADALCYAHTFNPKVIINAATLTGAMDIALGSGATGVFTNSSWLWNKLFE
ASIETGDRVWRMPLFEHYTRQVIDCQLADVNNIGKYRSAGACTAAAFLKEFVTHPKWAHL
DIAGVMTNKDEVPYLRKGMAGRPTRTLIEFLFRFSQDSA
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BDBM23985
NameBDBM23985
Synonyms:3,4-dihydro-1H-2-benzopyran-3-one | isochromanone, 4a
TypeSmall organic molecule
Emp. Form.C9H8O2
Mol. Mass.148.1586
SMILESO=C1Cc2ccccc2CO1
Structure
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BDBM23972
NameBDBM23972
Synonyms:(2S)-2-amino-4-methyl-N-(4-nitrophenyl)pentanamide | L-Leucine-p-nitroanilide | L-Leucine-para-nitroanilide
Typen/a
Emp. Form.C12H17N3O3
Mol. Mass.251.2817
SMILESCC(C)C[C@H](N)C(=O)Nc1ccc(cc1)[N+]([O-])=O |r|
Structure
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