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Target
Leukotriene A-4 hydrolase
Ligand
BDBM23985
Substrate
BDBM23991
Meas. Tech.
Enzyme Inhibition Assay
IC50
>1000000±n/a nM
Citation
 Albrecht, S; Defoin, A; Salomon, E; Tarnus, C; Wetterholm, A; Haeggström, JZ Synthesis and structure activity relationships of novel non-peptidic metallo-aminopeptidase inhibitors. Bioorg Med Chem 14:7241-57 (2006) [PubMed]  Article 
Target
Name:
Leukotriene A-4 hydrolase
Synonyms:
LKHA4_HUMAN | LTA-4 hydrolase | LTA4 | LTA4H | Leukotriene A(4) hydrolase | Leukotriene A-4 hydrolase (LTA4H) | Leukotriene A4 hydrolase
Type:
Hydrolase; metalloprotease
Mol. Mass.:
69280.41
Organism:
Homo sapiens (Human)
Description:
Human recombinant LTA4H.
Residue:
611
Sequence:
MPEIVDTCSLASPASVCRTKHLHLRCSVDFTRRTLTGTAALTVQSQEDNLRSLVLDTKDLTIEKVVINGQEVKYALGERQSYKGSPMEISLPIALSKNQEIVIEISFETSPKSSALQWLTPEQTSGKEHPYLFSQCQAIHCRAILPCQDTPSVKLTYTAEVSVPKELVALMSAIRDGETPDPEDPSRKIYKFIQKVPIPCYLIALVVGALESRQIGPRTLVWSEKEQVEKSAYEFSETESMLKIAEDLGGPYVWGQYDLLVLPPSFPYGGMENPCLTFVTPTLLAGDKSLSNVIAHEISHSWTGNLVTNKTWDHFWLNEGHTVYLERHICGRLFGEKFRHFNALGGWGELQNSVKTFGETHPFTKLVVDLTDIDPDVAYSSVPYEKGFALLFYLEQLLGGPEIFLGFLKAYVEKFSYKSITTDDWKDFLYSYFKDKVDVLNQVDWNAWLYSPGLPPIKPNYDMTLTNACIALSQRWITAKEDDLNSFNATDLKDLSSHQLNEFLAQTLQRAPLPLGHIKRMQEVYNFNAINNSEIRFRWLRLCIQSKWEDAIPLALKMATEQGRMKFTRPLFKDLAAFDKSHDQAVRTYQEHKASMHPVTAMLVGKDLKVD
  
Inhibitor
Name:
BDBM23985
Synonyms:
3,4-dihydro-1H-2-benzopyran-3-one | isochromanone, 4a
Type:
Small organic molecule
Emp. Form.:
C9H8O2
Mol. Mass.:
148.1586
SMILES:
O=C1Cc2ccccc2CO1
Structure:
Search PDB for entries with ligand similarity:
Substrate
Name:
BDBM23991
Synonyms:
(2S)-2-amino-N-(4-nitrophenyl)propanamide | Ala-4-nitroanilide | Alanine para-nitroanilide | L-Alanine-4-nitroanilide
Type:
n/a
Emp. Form.:
C9H11N3O3
Mol. Mass.:
209.2019
SMILES:
C[C@H](N)C(=O)Nc1ccc(cc1)[N+]([O-])=O |r|
Structure:
Search PDB for entries with ligand similarity: