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TargetLeukotriene A4 hydrolase
LigandBDBM24243
Substrate/CompetitorBDBM23991
Meas. Tech.Peptidase Assay
pH7.5±n/a
Temperature295.15±n/a K
IC50 280±n/a nM
Km1000000±n/a nM
Citation Kirkland, TAAdler, MBauman, JGChen, MHaeggström, JZKing, BKochanny, MJLiang, AMMendoza, LPhillips, GBThunnissen, MTrinh, LWhitlow, MYe, BYe, HParkinson, JGuilford, WJ Synthesis of glutamic acid analogs as potent inhibitors of leukotriene A4 hydrolase. Bioorg Med Chem16:4963-83 (2008) [PubMed]  Article
More Info.:Get all data from this article,  Inhibition_Run data,   Solution Info,  Assay Method
 
Leukotriene A4 hydrolase
Name:Leukotriene A4 hydrolase
Synonyms:LTA-4 hydrolase | Leukotriene A(4) hydrolase | Leukotriene A-4 hydrolase (LTA4H)
Type:Hydrolase; metalloprotease
Mol. Mass.:69280.41
Organism:Homo sapiens (Human)
Description:Human recombinant LTA4H.
Residue:611
Sequence:
MPEIVDTCSLASPASVCRTKHLHLRCSVDFTRRTLTGTAALTVQSQEDNLRSLVLDTKDL
TIEKVVINGQEVKYALGERQSYKGSPMEISLPIALSKNQEIVIEISFETSPKSSALQWLT
PEQTSGKEHPYLFSQCQAIHCRAILPCQDTPSVKLTYTAEVSVPKELVALMSAIRDGETP
DPEDPSRKIYKFIQKVPIPCYLIALVVGALESRQIGPRTLVWSEKEQVEKSAYEFSETES
MLKIAEDLGGPYVWGQYDLLVLPPSFPYGGMENPCLTFVTPTLLAGDKSLSNVIAHEISH
SWTGNLVTNKTWDHFWLNEGHTVYLERHICGRLFGEKFRHFNALGGWGELQNSVKTFGET
HPFTKLVVDLTDIDPDVAYSSVPYEKGFALLFYLEQLLGGPEIFLGFLKAYVEKFSYKSI
TTDDWKDFLYSYFKDKVDVLNQVDWNAWLYSPGLPPIKPNYDMTLTNACIALSQRWITAK
EDDLNSFNATDLKDLSSHQLNEFLAQTLQRAPLPLGHIKRMQEVYNFNAINNSEIRFRWL
RLCIQSKWEDAIPLALKMATEQGRMKFTRPLFKDLAAFDKSHDQAVRTYQEHKASMHPVT
AMLVGKDLKVD
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BDBM24243
NameBDBM24243
Synonyms:2-amino-N-[4-(benzyloxy)phenyl]acetamide | Amino acid analog, 2 | CHEMBL479960
TypeSmall organic molecule
Emp. Form.C15H16N2O2
Mol. Mass.256.2997
SMILESNCC(=O)Nc1ccc(OCc2ccccc2)cc1
Structure
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BDBM23991
NameBDBM23991
Synonyms:(2S)-2-amino-N-(4-nitrophenyl)propanamide | Ala-4-nitroanilide | Alanine para-nitroanilide | L-Alanine-4-nitroanilide
Typen/a
Emp. Form.C9H11N3O3
Mol. Mass.209.2019
SMILESC[C@H](N)C(=O)Nc1ccc(cc1)[N+]([O-])=O |r|
Structure
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