Reaction Details Report a problem with these data
Target
Histone deacetylase 1
Ligand
BDBM24621
Substrate
BDBM24619
Meas. Tech.
HDAC Inhibition Assay
pH
7.4±n/a
Temperature
295.15±n/a K
Ki
4±n/a nM
Citation
 Buggy, JJ; Cao, ZA; Bass, KE; Verner, E; Balasubramanian, S; Liu, L; Schultz, BE; Young, PR; Dalrymple, SA CRA-024781: a novel synthetic inhibitor of histone deacetylase enzymes with antitumor activity in vitro and in vivo. Mol Cancer Ther 5:1309-17 (2006) [PubMed]  Article 
Target
Name:
Histone deacetylase 1
Synonyms:
Cereblon/Histone deacetylase 1 | HD1 | HDAC1 | HDAC1_HUMAN | Histone deacetylase 1 (HDAC1) | Human HDAC1 | RPD3L1
Type:
Enzyme
Mol. Mass.:
55090.27
Organism:
Homo sapiens (Human)
Description:
Q13547
Residue:
482
Sequence:
MAQTQGTRRKVCYYYDGDVGNYYYGQGHPMKPHRIRMTHNLLLNYGLYRKMEIYRPHKANAEEMTKYHSDDYIKFLRSIRPDNMSEYSKQMQRFNVGEDCPVFDGLFEFCQLSTGGSVASAVKLNKQQTDIAVNWAGGLHHAKKSEASGFCYVNDIVLAILELLKYHQRVLYIDIDIHHGDGVEEAFYTTDRVMTVSFHKYGEYFPGTGDLRDIGAGKGKYYAVNYPLRDGIDDESYEAIFKPVMSKVMEMFQPSAVVLQCGSDSLSGDRLGCFNLTIKGHAKCVEFVKSFNLPMLMLGGGGYTIRNVARCWTYETAVALDTEIPNELPYNDYFEYFGPDFKLHISPSNMTNQNTNEYLEKIKQRLFENLRMLPHAPGVQMQAIPEDAIPEESGDEDEDDPDKRISICSSDKRIACEEEFSDSEEEGEGGRKNSSNFKKAKRVKTEDEKEKDPEEKKEVTEEEKTKEEKPEAKGVKEEVKLA
  
Inhibitor
Name:
BDBM24621
Synonyms:
CG-003 | N-{2-[4-(hydroxycarbamoyl)phenoxy]ethyl}-1-benzofuran-2-carboxamide
Type:
Small organic molecule
Emp. Form.:
C18H16N2O5
Mol. Mass.:
340.33
SMILES:
ONC(=O)c1ccc(OCCNC(=O)c2cc3ccccc3o2)cc1
Structure:
Search PDB for entries with ligand similarity:
Substrate
Name:
BDBM24619
Synonyms:
(2S)-6-acetamido-2-[(2S)-2-(2-acetamidoacetamido)propanamido]-N-(4-methyl-2-oxo-2H-chromen-7-yl)hexanamide | N-acetylglycyl-L-alanyl-N6-acetyl-N-(4-methyl-2-oxo-2H-chromen-7-yl)-L-lysinamide | acetyl-Gly-Ala-(N-acetyl-Lys)-AMC
Type:
Fluorogenic substrate
Emp. Form.:
C25H33N5O7
Mol. Mass.:
515.5588
SMILES:
C[C@H](NC(=O)CNC(C)=O)C(=O)N[C@@H](CCCCNC(C)=O)C(=O)Nc1ccc2c(C)cc(=O)oc2c1 |r|
Structure:
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