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Target
Transthyretin
Ligand
BDBM138373
Substrate
n/a
Meas. Tech.
The FP assay
IC50
4217±n/a nM
Citation
 Graef, IA; Alhamadsheh, MM Identification of stabilizers of multimeric proteins US Patent  US10278929 Publication Date 5/7/2019 
Target
Name:
Transthyretin
Synonyms:
ATTR | PALB | Prealbumin | TBPA | TTHY_HUMAN | TTR | Transthyretin (TTR)
Type:
Enzyme
Mol. Mass.:
15884.31
Organism:
Homo sapiens (Human)
Description:
P02766
Residue:
147
Sequence:
MASHRLLLLCLAGLVFVSEAGPTGTGESKCPLMVKVLDAVRGSPAINVAVHVFRKAADDTWEPFASGKTSESGELHGLTTEEEFVEGIYKVEIDTKSYWKALGISPFHEHAEVVFTANDSGPRRYTIAALLSPYSYSTTAVVTNPKE
  
Inhibitor
Name:
BDBM138373
Synonyms:
US10278929, Compound 21 | US11337935, Compound 21 | US8877795, 21
Type:
Small organic molecule
Emp. Form.:
C16H8ClF3O4
Mol. Mass.:
356.681
SMILES:
Oc1ccc2c(c1)oc(c(Oc1ccccc1Cl)c2=O)C(F)(F)F
Structure:
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