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Reaction Details
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TargetATP Phosphoribosyltransferase
LigandBDBM25325
Substrate/CompetitorBDBM25315
Meas. Tech.Enzyme Inhibition Assay
pH8.5±n/a
Temperature295.15±n/a K
Comments15% inhibition @ 10 uM.
Citation Cho, YIoerger, TRSacchettini, JC Discovery of novel nitrobenzothiazole inhibitors for Mycobacterium tuberculosis ATP phosphoribosyl transferase (HisG) through virtual screening. J Med Chem51:5984-92 (2008) [PubMed]  Article
More Info.:Get all data from this article,  Inhibition_Run data,   Solution Info,  Assay Method
 
ATP Phosphoribosyltransferase
Name:ATP Phosphoribosyltransferase
Synonyms:ATP-PRT | ATP-PRTase | hisG
Type:Glycosyltransferase
Mol. Mass.:30473.85
Organism:Mycobacterium tuberculosis
Description:n/a
Residue:284
Sequence:
MLRVAVPNKGALSEPATEILAEAGYRRRTDSKDLTVIDPVNNVEFFFLRPKDIAIYVGSG
ELDFGITGRDLVCDSGAQVRERLALGFGSSSFRYAAPAGRNWTTADLAGMRIATAYPNLV
RKDLATKGIEATVIRLDGAVEISVQLGVADAIADVVGSGRTLSQHDLVAFGEPLCDSEAV
LIERAGTDGQDQTEARDQLVARVQGVVFGQQYLMLDYDCPRSALKKATAITPGLESPTIA
PLADPDWVAIRALVPRRDVNGIMDELAAIGAKAILASDIRFCRF
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BDBM25325
NameBDBM25325
Synonyms:2-[methyl(6-nitro-1,3-benzothiazol-2-yl)amino]acetic acid | ChemBridge nitrobenzothiazole, 20
TypeSmall organic molecule
Emp. Form.C10H9N3O4S
Mol. Mass.267.261
SMILESCN(CC(O)=O)c1nc2ccc(cc2s1)[N+]([O-])=O
Structure
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BDBM25315
NameBDBM25315
Synonyms:Phosphoribosyl Pyrophosphate (PRPP) | {[(2R,3S,4R,5R)-3,4-dihydroxy-5-{[hydroxy(phosphonooxy)phosphoryl]oxy}oxolan-2-yl]methoxy}phosphonic acid
Type Pentosephosphate
Emp. Form.C5H13O14P3
Mol. Mass.390.0696
SMILESO[C@H]1[C@@H](O)[C@@H](OP(O)(=O)OP(O)(O)=O)O[C@@H]1COP(O)(O)=O |r|
Structure
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