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Target
Serine/threonine-protein kinase PLK3
Ligand
BDBM25521
Substrate
CHK2 Substrate Peptide
Meas. Tech.
Plk in Vitro Assay
pH
7.2±n/a
Temperature
303.15±n/a K
IC50
>10000±n/a nM
Citation
 Fucini, RV; Hanan, EJ; Romanowski, MJ; Elling, RA; Lew, W; Barr, KJ; Zhu, J; Yoburn, JC; Liu, Y; Fahr, BT; Fan, J; Lu, Y; Pham, P; Choong, IC; VanderPorten, EC; Bui, M; Purkey, HE; Evanchik, MJ; Yang, W Design and synthesis of 2-amino-pyrazolopyridines as Polo-like kinase 1 inhibitors. Bioorg Med Chem Lett 18:5648-52 (2008) [PubMed]  Article 
Target
Name:
Serine/threonine-protein kinase PLK3
Synonyms:
CNK | Cytokine-inducible serine/threonine-protein kinase | FGF-inducible kinase | FNK | PLK3 | PLK3_HUMAN | PRK | Polo-Like Kinase 3 | Proliferation-related kinase | Serine/threonine-protein kinase PLK3
Type:
Serine/threonine-protein kinase
Mol. Mass.:
71655.17
Organism:
Homo sapiens (Human)
Description:
Enzyme assays were using PLK3 purified from baculovirus-infected Trichoplusia ni cells expressing full-length PLK3.
Residue:
646
Sequence:
MEPAAGFLSPRPFQRAAAAPAPPAGPGPPPSALRGPELEMLAGLPTSDPGRLITDPRSGRTYLKGRLLGKGGFARCYEATDTETGSAYAVKVIPQSRVAKPHQREKILNEIELHRDLQHRHIVRFSHHFEDADNIYIFLELCSRKSLAHIWKARHTLLEPEVRYYLRQILSGLKYLHQRGILHRDLKLGNFFITENMELKVGDFGLAARLEPPEQRKKTICGTPNYVAPEVLLRQGHGPEADVWSLGCVMYTLLCGSPPFETADLKETYRCIKQVHYTLPASLSLPARQLLAAILRASPRDRPSIDQILRHDFFTKGYTPDRLPISSCVTVPDLTPPNPARSLFAKVTKSLFGRKKKSKNHAQERDEVSGLVSGLMRTSVGHQDARPEAPAASGPAPVSLVETAPEDSSPRGTLASSGDGFEEGLTVATVVESALCALRNCIAFMPPAEQNPAPLAQPEPLVWVSKWVDYSNKFGFGYQLSSRRVAVLFNDGTHMALSANRKTVHYNPTSTKHFSFSVGAVPRALQPQLGILRYFASYMEQHLMKGGDLPSVEEVEVPAPPLLLQWVKTDQALLMLFSDGTVQVNFYGDHTKLILSGWEPLLVTFVARNRSACTYLASHLRQLGCSPDLRQRLRYALRLLRDRSPA
  
Inhibitor
Name:
BDBM25521
Synonyms:
2-amino-pyrazolopyridine, 37 | N-{2-[3-chloro-5-(3-methyl-6-{[(1S)-1-phenylethyl]amino}-1H-pyrazolo[4,3-c]pyridin-1-yl)phenyl]phenyl}acetamide
Type:
Small organic molecule
Emp. Form.:
C29H26ClN5O
Mol. Mass.:
496.003
SMILES:
C[C@H](Nc1cc2n(nc(C)c2cn1)-c1cc(Cl)cc(c1)-c1ccccc1NC(C)=O)c1ccccc1 |r|
Structure:
Search PDB for entries with ligand similarity:
Substrate
Name:
CHK2 Substrate Peptide
Synonyms:
CHK2tide
Type:
Fluorophore tagged peptide
Mol. Mass.:
1755.03
Organism:
n/a
Description:
n/a
Residue:
14
Sequence:
AMRLERQDSIFYPK