Target
Aurora kinase A
Ligand
BDBM25723
Substrate
CHOCKtide
Meas. Tech.
Aurora Kinase SPA Assay
IC50
4400±n/a nM
Citation
 Andersen, CBWan, YChang, JWRiggs, BLee, CLiu, YSessa, FVilla, FKwiatkowski, NSuzuki, MNallan, LHeald, RMusacchio, AGray, NS Discovery of selective aminothiazole aurora kinase inhibitors. ACS Chem Biol 3:180-92 (2008) [PubMed]  Article 
Target
Name:
Aurora kinase A
Synonyms:
AIK | AIRK1 | ARK1 | AURA | AURKA | AURKA_HUMAN | AYK1 | Aurora 2 | Aurora kinase A (AURA) | Aurora kinase A (AURKA) | Aurora kinase A (Aurora A) | Aurora kinase A (Aurora-2) | Aurora-related kinase 1 | Aurora/IPL1-related kinase 1 | BTAK | Breast tumor-amplified kinase | Breast-tumor-amplified kinase | IAK1 | STK15 | STK6 | Serine/threonine kinase 15 | Serine/threonine-protein kinase 6 | Serine/threonine-protein kinase aurora A | aurora-2 | hARK1
Type:
Serine/threonine-protein kinase
Mol. Mass.:
45830.98
Organism:
Homo sapiens (Human)
Description:
O14965
Residue:
403
Sequence:
MDRSKENCISGPVKATAPVGGPKRVLVTQQFPCQNPLPVNSGQAQRVLCPSNSSQRVPLQAQKLVSSHKPVQNQKQKQLQATSVPHPVSRPLNNTQKSKQPLPSAPENNPEEELASKQKNEESKKRQWALEDFEIGRPLGKGKFGNVYLAREKQSKFILALKVLFKAQLEKAGVEHQLRREVEIQSHLRHPNILRLYGYFHDATRVYLILEYAPLGTVYRELQKLSKFDEQRTATYITELANALSYCHSKRVIHRDIKPENLLLGSAGELKIADFGWSVHAPSSRRTTLCGTLDYLPPEMIEGRMHDEKVDLWSLGVLCYEFLVGKPPFEANTYQETYKRISRVEFTFPDFVTEGARDLISRLLKHNPSQRPMLREVLEHPWITANSSKPSNCQNKESASKQS
  
Inhibitor
Name:
BDBM25723
Synonyms:
2-({5-[(4-ethylpiperazin-1-yl)methyl]pyridin-2-yl}amino)-1,3-thiazole-5-carbonitrile | aminothiazole analogue, 72
Type:
Small organic molecule
Emp. Form.:
C16H20N6S
Mol. Mass.:
328.435
SMILES:
CCN1CCN(Cc2ccc(Nc3ncc(s3)C#N)nc2)CC1
Structure:
Search PDB for entries with ligand similarity:
Substrate
Name:
CHOCKtide
Synonyms:
n/a
Type:
Peptide
Mol. Mass.:
889.06
Organism:
n/a
Description:
n/a
Residue:
7
Sequence:
LRRWSLG