Reaction Details Report a problem with these data
Target
Beta-2 adrenergic receptor
Ligand
BDBM25767
Substrate
BDBM25747
Meas. Tech.
3H-CGP 12177 Whole Cell Binding Assay
Kd
0.21±n/a nM
Citation
 Baker, JG The selectivity of beta-adrenoceptor antagonists at the human beta1, beta2 and beta3 adrenoceptors. Br J Pharmacol 144:317-22 (2005) [PubMed]  Article 
Target
Name:
Beta-2 adrenergic receptor
Synonyms:
ADRB2 | ADRB2R | ADRB2_HUMAN | B2AR | Beta-2 adrenoceptor | Beta-2 adrenoreceptor
Type:
n/a
Mol. Mass.:
46461.69
Organism:
Homo sapiens (Human)
Description:
P07550
Residue:
413
Sequence:
MGQPGNGSAFLLAPNGSHAPDHDVTQERDEVWVVGMGIVMSLIVLAIVFGNVLVITAIAKFERLQTVTNYFITSLACADLVMGLAVVPFGAAHILMKMWTFGNFWCEFWTSIDVLCVTASIETLCVIAVDRYFAITSPFKYQSLLTKNKARVIILMVWIVSGLTSFLPIQMHWYRATHQEAINCYANETCCDFFTNQAYAIASSIVSFYVPLVIMVFVYSRVFQEAKRQLQKIDKSEGRFHVQNLSQVEQDGRTGHGLRRSSKFCLKEHKALKTLGIIMGTFTLCWLPFFIVNIVHVIQDNLIRKEVYILLNWIGYVNSGFNPLIYCRSPDFRIAFQELLCLRRSSLKAYGNGYSSNGNTGEQSGYHVEQEKENKLLCEDLPGTEDFVGHQGTVPSDNIDSQGRNCSTNDSLL
  
Inhibitor
Name:
BDBM25767
Synonyms:
Timolol | racemic-Timolol | tert-butyl(2-hydroxy-3-{[4-(morpholin-4-yl)-1,2,5-thiadiazol-3-yl]oxy}propyl)amine
Type:
Small organic molecule
Emp. Form.:
C13H24N4O3S
Mol. Mass.:
316.42
SMILES:
CC(C)(C)NCC(O)COc1nsnc1N1CCOCC1
Structure:
Search PDB for entries with ligand similarity:
Substrate
Name:
BDBM25747
Synonyms:
4-[3-(tert-butylamino)-2-hydroxypropoxy]-2,3-dihydro-1H-1,3-benzodiazol-2-one hydrochloride | CGP 12177 | CGP-12177 | CGP12177 | [3H]CGP 12177
Type:
radiolabeled ligand
Emp. Form.:
C14H21N3O3
Mol. Mass.:
279.3348
SMILES:
CC(C)(C)NCC(O)COc1cccc2[nH]c(=O)[nH]c12
Structure:
Search PDB for entries with ligand similarity: