Reaction Details Report a problem with these data
Target
Lysine-specific demethylase 4E
Ligand
BDBM26108
Substrate
Histone H3 fragment substrate
Meas. Tech.
FDH Coupled Inhibition Assay
pH
7.5±n/a
Temperature
310.15±n/a K
IC50
100000±n/a nM
Comments
IC50=39 uM with 30 min preincubation.
Citation
 Rose, NR; Ng, SS; Mecinovic;, J; Liénard, MR; Bello, SH; Sun, Z; McDonough, MA; Oppermann, U; Schofield, CJ Inhibitor Scaffolds for 2-Oxoglutarate-Dependent Histone Lysine Demethylases. J Med Chem 51:7053-6 (2008) [PubMed]  Article 
Target
Name:
Lysine-specific demethylase 4E
Synonyms:
2-OG-Dependent Histone Demethylase JMJD2E | Histone Lysine Demethylase | Jumonji domain-containing protein 2E (JMJD2E) | KDM4D-like protein | KDM4DL | KDM4E | KDM4E_HUMAN | Lysine-specific demethylase 4D-like | Lysine-specific demethylase 4E | Lysine-specific demethylase 4E (KDM4E)
Type:
Enzyme
Mol. Mass.:
56815.71
Organism:
Homo sapiens (Human)
Description:
B2RXH2
Residue:
506
Sequence:
MKSVHSSPQNTSHTIMTFYPTMEEFADFNTYVAYMESQGAHQAGLAKVIPPKEWKARQMYDDIEDILIATPLQQVTSGQGGVFTQYHKKKKAMRVGQYRRLANSKKYQTPPHQNFADLEQRYWKSHPGNPPIYGADISGSLFEESTKQWNLGHLGTILDLLEQECGVVIEGVNTPYLYFGMWKTTFAWHTEDMDLYSINYLHFGEPKTWYVVPPEHGQHLERLARELFPDISRGCEAFLRHKVALISPTVLKENGIPFNCMTQEAGEFMVTFPYGYHAGFNHGFNCAEAINFATPRWIDYGKMASQCSCGESTVTFSMDPFVRIVQPESYELWKHRQDLAIVEHTEPRVAESQELSNWRDDIVLRRAALGLRLLPNLTAQCPTQPVSSGHCYNPKGCGTDAVPGSAFQSSAYHTQTQSLTLGMSARVLLPSTGSWGSGRGRGRGQGQGRGCSRGRGHGCCTRELGTEEPTVQPASKRRLLMGTRSRAQGHRPQLPLANDLMTNLSL
  
Inhibitor
Name:
BDBM26108
Synonyms:
(2R)-2-(formamidoformic acid)-4-phenylbutanoic acid | N-Oxalyl-D-homophenylalanine, 1c
Type:
Small organic molecule
Emp. Form.:
C12H13NO5
Mol. Mass.:
251.2353
SMILES:
OC(=O)[C@@H](CCc1ccccc1)NC(=O)C(O)=O |r|
Structure:
Search PDB for entries with ligand similarity:
Substrate
Name:
Histone H3 fragment substrate
Synonyms:
H3K9me3
Type:
8-mer
Mol. Mass.:
1066.23
Organism:
n/a
Description:
2-OG as co-substrate.
Residue:
10
Sequence:
ARKMESTGGK