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Target
Lysine-specific demethylase 4E
Ligand
BDBM26113
Substrate
Histone H3 fragment substrate
Meas. Tech.
FDH Coupled Inhibition Assay
pH
7.5±n/a
Temperature
310.15±n/a K
IC50
1400±n/a nM
Citation
 Rose, NR; Ng, SS; Mecinovic;, J; Liénard, MR; Bello, SH; Sun, Z; McDonough, MA; Oppermann, U; Schofield, CJ Inhibitor Scaffolds for 2-Oxoglutarate-Dependent Histone Lysine Demethylases. J Med Chem 51:7053-6 (2008) [PubMed]  Article 
Target
Name:
Lysine-specific demethylase 4E
Synonyms:
2-OG-Dependent Histone Demethylase JMJD2E | Histone Lysine Demethylase | Jumonji domain-containing protein 2E (JMJD2E) | KDM4D-like protein | KDM4DL | KDM4E | KDM4E_HUMAN | Lysine-specific demethylase 4D-like | Lysine-specific demethylase 4E | Lysine-specific demethylase 4E (KDM4E)
Type:
Enzyme
Mol. Mass.:
56815.71
Organism:
Homo sapiens (Human)
Description:
B2RXH2
Residue:
506
Sequence:
MKSVHSSPQNTSHTIMTFYPTMEEFADFNTYVAYMESQGAHQAGLAKVIPPKEWKARQMYDDIEDILIATPLQQVTSGQGGVFTQYHKKKKAMRVGQYRRLANSKKYQTPPHQNFADLEQRYWKSHPGNPPIYGADISGSLFEESTKQWNLGHLGTILDLLEQECGVVIEGVNTPYLYFGMWKTTFAWHTEDMDLYSINYLHFGEPKTWYVVPPEHGQHLERLARELFPDISRGCEAFLRHKVALISPTVLKENGIPFNCMTQEAGEFMVTFPYGYHAGFNHGFNCAEAINFATPRWIDYGKMASQCSCGESTVTFSMDPFVRIVQPESYELWKHRQDLAIVEHTEPRVAESQELSNWRDDIVLRRAALGLRLLPNLTAQCPTQPVSSGHCYNPKGCGTDAVPGSAFQSSAYHTQTQSLTLGMSARVLLPSTGSWGSGRGRGRGQGQGRGCSRGRGHGCCTRELGTEEPTVQPASKRRLLMGTRSRAQGHRPQLPLANDLMTNLSL
  
Inhibitor
Name:
BDBM26113
Synonyms:
2,4 PDCA | cid_10365 | pyridine carboxylate, 6a | pyridine-2,4-dicarboxylic acid
Type:
Small organic molecule
Emp. Form.:
C7H5NO4
Mol. Mass.:
167.1189
SMILES:
OC(=O)c1ccnc(c1)C(O)=O
Structure:
Search PDB for entries with ligand similarity:
Substrate
Name:
Histone H3 fragment substrate
Synonyms:
H3K9me3
Type:
8-mer
Mol. Mass.:
1066.23
Organism:
n/a
Description:
2-OG as co-substrate.
Residue:
10
Sequence:
ARKMESTGGK