Target
Proto-oncogene tyrosine-protein kinase LCK
Ligand
BDBM26166
Substrate
Biotinylated Peptide Substrate
Meas. Tech.
Time Resolved Fluorescence Resonance Energy Transfer Assay
pH
7.4±n/a
Temperature
295.15±n/a K
IC50
8.5±n/a nM
Citation
 Bamborough, PAngell, RMBhamra, IBrown, DBull, JChristopher, JACooper, AWFazal, LHGiordano, IHind, LPatel, VKRanshaw, LESims, MJSkone, PASmith, KJVickerstaff, EWashington, M N-4-Pyrimidinyl-1H-indazol-4-amine inhibitors of Lck: indazoles as phenol isosteres with improved pharmacokinetics. Bioorg Med Chem Lett 17:4363-8 (2007) [PubMed]  Article
Target
Name:
Proto-oncogene tyrosine-protein kinase LCK
Synonyms:
LSK | Lck | Lymphocyte cell-specific protein-tyrosine kinase | Proto-oncogene tyrosine-protein kinase LCK | Tyrosine-protein kinase LCK | p56-LCK
Type:
PROTEIN
Mol. Mass.:
57927.84
Organism:
Mus musculus
Description:
ChEMBL_806408
Residue:
509
Sequence:
MGCVCSSNPEDDWMENIDVCENCHYPIVPLDSKISLPIRNGSEVRDPLVTYEGSLPPASPLQDNLVIALHSYEPSHDGDLGFEKGEQLRILEQSGEWWKAQSLTTGQEGFIPFNFVAKANSLEPEPWFFKNLSRKDAERQLLAPGNTHGSFLIRESESTAGSFSLSVRDFDQNQGEVVKHYKIRNLDNGGFYISPRITFPGLHDLVRHYTNASDGLCTKLSRPCQTQKPQKPWWEDEWEVPRETLKLVERLGAGQFGEVWMGYYNGHTKVAVKSLKQGSMSPDAFLAEANLMKQLQHPRLVRLYAVVTQEPIYIITEYMENGSLVDFLKTPSGIKLNVNKLLDMAAQIAEGMAFIEEQNYIHRDLRAANILVSDTLSCKIADFGLARLIEDNEYTAREGAKFPIKWTAPEAINYGTFTIKSDVWSFGILLTEIVTHGRIPYPGMTNPEVIQNLERGYRMVRPDNCPEELYHLMMLCWKERPEDRPTFDYLRSVLDDFFTATEGQYQPQP
  
Inhibitor
Name:
BDBM26166
Synonyms:
2,4-dianilino pyrimidine, 23 | 3-({4-[(5-hydroxy-2-methylphenyl)amino]pyrimidin-2-yl}amino)benzene-1-sulfonamide
Type:
Small organic molecule
Emp. Form.:
C17H17N5O3S
Mol. Mass.:
371.414
SMILES:
Cc1ccc(O)cc1Nc1ccnc(Nc2cccc(c2)S(N)(=O)=O)n1
Structure:
Search PDB for entries with ligand similarity:
Substrate
Name:
Biotinylated Peptide Substrate
Synonyms:
n/a
Type:
Peptide
Mol. Mass.:
1622.70
Organism:
n/a
Description:
n/a
Residue:
13
Sequence:
ITINEEEEYFELV