| Reaction Details |
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| Report a problem with these data |
| Target | Histamine H3 Receptor |
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| Ligand | JNJ 7777120 |
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| Substrate/Competitor | [3H]N-alpha-methyl histamine |
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| Meas. Tech. | Radioligand Binding Assay |
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| pH | 7.4±n/a |
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| Temperature | 298.15±n/a K |
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| Ki | 1318±260 nM |
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| Citation |  Altenbach, RJ; Adair, RM; Bettencourt, BM; Black, LA; Fix-Stenzel, SR; Gopalakrishnan, SM; Hsieh, GC; Liu, H; Marsh, KC; McPherson, MJ; Milicic, I; Miller, TR; Vortherms, TA; Warrior, U; Wetter, JM; Wishart, N; Witte, DG; Honore, P; Esbenshade, TA; Hancock, AA; Brioni, JD; Cowart, MD Structure-activity studies on a series of a 2-aminopyrimidine-containing histamine H4 receptor ligands.J Med Chem.51:6571-80(2008)[PubMed] |
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| More Info. |
Get all data from this article
, Solution Info
, Assay Method
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| Histamine H3 Receptor |
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| Name | Histamine H3 Receptor |
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| Synonyms | HH3R |
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| Type | G Protein-Coupled Receptor (GPCR) |
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| Mol. Mass. | 48588 |
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| Organism | Rattus norvegicus (rat) |
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| Description | Radioligand binding assays were using rat cortical membranes. |
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| Residue | 445 |
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| Sequence | MERAPPDGLMNASGTLAGEAAAAGGARGFSAAWTAVLAALMALLIVATVLGNALVMLAFV
ADSSLRTQNNFFLLNLAISDFLVGAFCIPLYVPYVLTGRWTFGRGLCKLWLVVDYLLCAS
SVFNIVLISYDRFLSVTRAVSYRAQQGDTRRAVRKMALVWVLAFLLYGPAILSWEYLSGG
SSIPEGHCYAEFFYNWYFLITASTLEFFTPFLSVTFFNLSIYLNIQRRTRLRLDGGREAG
PEPPPDAQPSPPPAPPSCWGCWPKGHGEAMPLHRYGVGEAGPGVEAGEAALGGGSGGGAA
ASPTSSSGSSSRGTERPRSLKRGSKPSASSASLEKRMKMVSQSITQRFRLSRDKKVAKSL
AIIVSIFGLCWAPYTLLMIIRAACHGRCIPDYWYETSFWLLWANSAVNPVLYPLCHYSFR
RAFTKLLCPQKLKVQPHGSLEQCWK
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| JNJ 7777120 |
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| Name | JNJ 7777120 |
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| Synonyms: | 5-chloro-2-[(4-methylpiperazin-1-yl)carbonyl]-1H-indole |
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| Type | Small organic molecule |
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| Emp. Form. | C14H16ClN3O |
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| Mol. Mass. | 277.749 |
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| SMILES | CN1CCN(CC1)C(=O)c1cc2cc(Cl)ccc2[nH]1 |
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| Structure | |
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| [3H]N-alpha-methyl histamine |
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| Name | [3H]N-alpha-methyl histamine |
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| Synonyms: | N-alpha-methylhistamine | N-methylhistamine | [2-(1H-imidazol-5-yl)ethyl](methyl)amine |
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| Type | radiolabeled ligand |
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| Emp. Form. | C6H11N3 |
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| Mol. Mass. | 125.1716 |
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| SMILES | CNCCc1cnc[nH]1 |
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| Structure | |
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