| Reaction Details |
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 | Report a problem with these data |
| Target | Serine/threonine-protein kinase pim-1 |
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| Ligand | BDBM26656 |
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| Substrate/Competitor | GST-BAD |
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| Meas. Tech. | Solid-Phase ELISA Kinase Assay |
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| pH | 7±n/a |
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| Temperature | 303.15±n/a K |
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| IC50 | 650±n/a nM |
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| Citation |  Holder, S; Zemskova, M; Zhang, C; Tabrizizad, M; Bremer, R; Neidigh, JW; Lilly, MB Characterization of a potent and selective small-molecule inhibitor of the PIM1 kinase. Mol Cancer Ther6:163-72 (2007) [PubMed] Article |
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| More Info.: | Get all data from this article, Solution Info, Assay Method |
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| Serine/threonine-protein kinase pim-1 |
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| Name: | Serine/threonine-protein kinase PIM |
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| Synonyms: | PIM-1 Kinase | PIM1 | Proto-oncogene serine/threonine-protein kinase Pim-1 | Serine/threonine-protein kinase (PIM1) | Serine/threonine-protein kinase PIM1 | Serine/threonine-protein kinase pim-1 (PIM1) |
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| Type: | Protein |
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| Mol. Mass.: | 35681.82 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P11309 |
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| Residue: | 313 |
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| Sequence: | MLLSKINSLAHLRAAPCNDLHATKLAPGKEKEPLESQYQVGPLLGSGGFGSVYSGIRVSD
NLPVAIKHVEKDRISDWGELPNGTRVPMEVVLLKKVSSGFSGVIRLLDWFERPDSFVLIL
ERPEPVQDLFDFITERGALQEELARSFFWQVLEAVRHCHNCGVLHRDIKDENILIDLNRG
ELKLIDFGSGALLKDTVYTDFDGTRVYSPPEWIRYHRYHGRSAAVWSLGILLYDMVCGDI
PFEHDEEIIRGQVFFRQRVSSECQHLIRWCLALRPSDRPTFEEIQNHPWMQDVLLPQETA
EIHLHSLSPGPSK
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| BDBM26656 |
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| Name | BDBM26656 |
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| Synonyms: | 5,7,3,4,5-pentahydroxyflavone | 5,7-dihydroxy-2-(3,4,5-trihydroxyphenyl)-4H-chromen-4-one |
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| Type | Flavonoid |
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| Emp. Form. | C15H10O7 |
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| Mol. Mass. | 302.2357 |
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| SMILES | Oc1cc(O)c2c(c1)oc(cc2=O)-c1cc(O)c(O)c(O)c1 |
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| Structure |  |
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| GST-BAD |
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| Name: | GST-BAD |
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| Synonyms: | GST fusion protein of Bcl2 antagonist of cell death |
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| Type: | Other Protein Type |
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| Mol. Mass.: | 22084.58 |
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| Organism: | Mus musculus (mouse) |
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| Description: | n/a |
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| Residue: | 204 |
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| Sequence: | MGTPKQPSLAPAHALGLRKSDPGIRSLGSDAGGRRWRPAAQSMFQIPEFEPSEQEDASAT
DRGLGPSLTEDQPGPYLAPGLLGSNIHQQGRAATNSHHGGAGAMETRSRHSSYPAGTEED
EGMEEELSPFRGRSRSAPPNLWAAQRYGRELRRMSDEFEGSFKGLPRPKSAGTATQMRQS
AGWTRIIQSWWDRNLGKGGSTPSQ
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