Target
Serine/threonine-protein kinase pim-1
Ligand
BDBM26659
Substrate
GST-BAD
Meas. Tech.
Solid-Phase ELISA Kinase Assay
pH
7±n/a
Temperature
303.15±n/a K
IC50
4520±n/a nM
Citation
 Holder, SZemskova, MZhang, CTabrizizad, MBremer, RNeidigh, JWLilly, MB Characterization of a potent and selective small-molecule inhibitor of the PIM1 kinase. Mol Cancer Ther 6:163-72 (2007) [PubMed]  Article 
Target
Name:
Serine/threonine-protein kinase pim-1
Synonyms:
PIM-1 Kinase | PIM1 | PIM1_HUMAN | Proto-oncogene serine/threonine-protein kinase Pim-1 | Serine/threonine-protein kinase (PIM1) | Serine/threonine-protein kinase PIM | Serine/threonine-protein kinase PIM1 | Serine/threonine-protein kinase pim-1 (PIM1)
Type:
Protein
Mol. Mass.:
35681.82
Organism:
Homo sapiens (Human)
Description:
P11309
Residue:
313
Sequence:
MLLSKINSLAHLRAAPCNDLHATKLAPGKEKEPLESQYQVGPLLGSGGFGSVYSGIRVSDNLPVAIKHVEKDRISDWGELPNGTRVPMEVVLLKKVSSGFSGVIRLLDWFERPDSFVLILERPEPVQDLFDFITERGALQEELARSFFWQVLEAVRHCHNCGVLHRDIKDENILIDLNRGELKLIDFGSGALLKDTVYTDFDGTRVYSPPEWIRYHRYHGRSAAVWSLGILLYDMVCGDIPFEHDEEIIRGQVFFRQRVSSECQHLIRWCLALRPSDRPTFEEIQNHPWMQDVLLPQETAEIHLHSLSPGPSK
  
Inhibitor
Name:
BDBM26659
Synonyms:
7,3-dihydroxyflavone | 7-hydroxy-2-(3-hydroxyphenyl)-4H-chromen-4-one
Type:
Flavonoid
Emp. Form.:
C15H10O4
Mol. Mass.:
254.2375
SMILES:
Oc1cccc(c1)-c1cc(=O)c2ccc(O)cc2o1
Structure:
Search PDB for entries with ligand similarity:
Substrate
Name:
Bcl2-associated agonist of cell death
Synonyms:
BAD_MOUSE | Bad | Bbc6 | GST fusion protein of Bcl2 antagonist of cell death | GST-BAD
Type:
Other Protein Type
Mol. Mass.:
22084.58
Organism:
Mus musculus (mouse)
Description:
n/a
Residue:
204
Sequence:
MGTPKQPSLAPAHALGLRKSDPGIRSLGSDAGGRRWRPAAQSMFQIPEFEPSEQEDASATDRGLGPSLTEDQPGPYLAPGLLGSNIHQQGRAATNSHHGGAGAMETRSRHSSYPAGTEEDEGMEEELSPFRGRSRSAPPNLWAAQRYGRELRRMSDEFEGSFKGLPRPKSAGTATQMRQSAGWTRIIQSWWDRNLGKGGSTPSQ