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Target
Serine/threonine-protein kinase pim-1
Ligand
BDBM26707
Substrate
Biotinylated Substrate Peptide
Meas. Tech.
Pim Kinase Assay
pH
7.5±n/a
Temperature
295.15±n/a K
Ki
2.5±n/a nM
Citation
 Tong, Y; Stewart, KD; Thomas, S; Przytulinska, M; Johnson, EF; Klinghofer, V; Leverson, J; McCall, O; Soni, NB; Luo, Y; Lin, NH; Sowin, TJ; Giranda, VL; Penning, TD Isoxazolo[3,4-b]quinoline-3,4(1H,9H)-diones as unique, potent and selective inhibitors for Pim-1 and Pim-2 kinases: chemistry, biological activities, and molecular modeling. Bioorg Med Chem Lett 18:5206-8 (2008) [PubMed]  Article 
Target
Name:
Serine/threonine-protein kinase pim-1
Synonyms:
PIM-1 Kinase | PIM1 | PIM1_HUMAN | Proto-oncogene serine/threonine-protein kinase Pim-1 | Serine/threonine-protein kinase (PIM1) | Serine/threonine-protein kinase PIM | Serine/threonine-protein kinase PIM1 | Serine/threonine-protein kinase pim-1 (PIM1)
Type:
Protein
Mol. Mass.:
35681.82
Organism:
Homo sapiens (Human)
Description:
P11309
Residue:
313
Sequence:
MLLSKINSLAHLRAAPCNDLHATKLAPGKEKEPLESQYQVGPLLGSGGFGSVYSGIRVSDNLPVAIKHVEKDRISDWGELPNGTRVPMEVVLLKKVSSGFSGVIRLLDWFERPDSFVLILERPEPVQDLFDFITERGALQEELARSFFWQVLEAVRHCHNCGVLHRDIKDENILIDLNRGELKLIDFGSGALLKDTVYTDFDGTRVYSPPEWIRYHRYHGRSAAVWSLGILLYDMVCGDIPFEHDEEIIRGQVFFRQRVSSECQHLIRWCLALRPSDRPTFEEIQNHPWMQDVLLPQETAEIHLHSLSPGPSK
  
Inhibitor
Name:
BDBM26707
Synonyms:
7-chloro-9-ethyl-6-hydroxy-1H,3H,4H,9H-quinolino[2,3-c][1,2]oxazole-3,4-dione | Isoxazoloquinolinedione, 19
Type:
Small organic molecule
Emp. Form.:
C12H9ClN2O4
Mol. Mass.:
280.664
SMILES:
CCn1c2noc(=O)c2c(O)c2cc(O)c(Cl)cc12
Structure:
Search PDB for entries with ligand similarity:
Substrate
Name:
Ryanodine receptor 1 [4317-4329]
Synonyms:
Biotinylated Substrate Peptide | RYDR | RYR1 | RYR1_HUMAN
Type:
Peptide
Mol. Mass.:
2871.44
Organism:
n/a
Description:
P21817[4317-4329]
Residue:
24
Sequence:
ITINCLINKERVRRLRRLTAREAA