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Target
Probable G-protein coupled receptor 139
Ligand
BDBM263495
Substrate
n/a
Meas. Tech.
Competition Binding
pH
7.4±n/a
Temperature
277.15±n/a K
Ki
352±n/a nM
Comments
extracted
Citation
 Hitchcock, S; Lam, B; Monenschein, H; Reichard, H 4-oxo-3,4-dihydro-1,2,3-benzotriazine modulators of GPR139 US Patent  US9556130 Publication Date 1/31/2017 
Target
Name:
Probable G-protein coupled receptor 139
Synonyms:
G(q)-coupled orphan receptor GPRg1 | G-protein coupled receptor 139 | G-protein-coupled receptor PGR3 | GP139_HUMAN | GPR139 | GPRG1 | GPRG1 | PGR3 | Probable G-protein coupled receptor 139
Type:
PROTEIN
Mol. Mass.:
40700.34
Organism:
Homo sapiens (Human)
Description:
ChEMBL_109920
Residue:
353
Sequence:
MEHTHAHLAANSSLSWWSPGSACGLGFVPVVYYSLLLCLGLPANILTVIILSQLVARRQKSSYNYLLALAAADILVLFFIVFVDFLLEDFILNMQMPQVPDKIIEVLEFSSIHTSIWITVPLTIDRYIAVCHPLKYHTVSYPARTRKVIVSVYITCFLTSIPYYWWPNIWTEDYISTSVHHVLIWIHCFTVYLVPCSIFFILNSIIVYKLRRKSNFRLRGYSTGKTTAILFTITSIFATLWAPRIIMILYHLYGAPIQNRWLVHIMSDIANMLALLNTAINFFLYCFISKRFRTMAAATLKAFFKCQKQPVQFYTNHNFSITSSPWISPANSHCIKMLVYQYDKNGKPIKVSP
  
Inhibitor
Name:
BDBM263495
Synonyms:
(s)-2-(8-methoxy-4-oxobenzo[d][1,2,3]triazin-3 (4h)-yl)-n-(1-(4-(trifluoromethyl)phenyl)ethyl)acetamide | US10561662, Example 63 | US11173161, EX 63 | US9556130, test 63
Type:
Small organic molecule
Emp. Form.:
C19H17F3N4O3
Mol. Mass.:
406.3585
SMILES:
COc1cccc2c1nnn(CC(=O)N[C@@H](C)c1ccc(cc1)C(F)(F)F)c2=O |r|
Structure:
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