Target
Cell division cycle 7-related protein kinase [58-574]/Protein DBF4 homolog A
Ligand
BDBM27368
Substrate
MCM2
Meas. Tech.
In Vitro Kinase Assay
pH
7.9±n/a
Temperature
298.15±n/a K
IC50
4±2 nM
Citation
 Menichincheri, MBargiotti, ABerthelsen, JBertrand, JABossi, RCiavolella, ACirla, ACristiani, CCroci, VD'Alessio, RFasolini, MFiorentini, FForte, BIsacchi, AMartina, KMolinari, AMontagnoli, AOrsini, POrzi, FPesenti, EPezzetta, DPillan, APoggesi, IRoletto, FScolaro, ATatò, MTibolla, MValsasina, BVarasi, MVolpi, DSantocanale, CVanotti, E First Cdc7 kinase inhibitors: pyrrolopyridinones as potent and orally active antitumor agents. 2. Lead discovery. J Med Chem 52:293-307 (2009) [PubMed]  Article 
Target
Name:
Cell division cycle 7-related protein kinase [58-574]/Protein DBF4 homolog A
Synonyms:
Cdc7 Kinase | Cdc7/DBF4
Type:
Protein Complex
Mol. Mass.:
n/a
Description:
n/a
Components:
This complex has 2 components.
Component 1
Name:
Cell division cycle 7-related protein kinase [58-574]
Synonyms:
CDC7 | CDC7L1 | CDC7_HUMAN | Cdc7 Kinase | Cell division cycle 7-related protein kinase
Type:
Serine/threonine-protein kinase
Mol. Mass.:
57470.88
Organism:
Homo sapiens (Human)
Description:
O00311[58-574]
Residue:
517
Sequence:
FKIEDKIGEGTFSSVYLATAQLQVGPEEKIALKHLIPTSHPIRIAAELQCLTVAGGQDNVMGVKYCFRKNDHVVIAMPYLEHESFLDILNSLSFQEVREYMLNLFKALKRIHQFGIVHRDVKPSNFLYNRRLKKYALVDFGLAQGTHDTKIELLKFVQSEAQQERCSQNKSHIITGNKIPLSGPVPKELDQQSTTKASVKRPYTNAQIQIKQGKDGKEGSVGLSVQRSVFGERNFNIHSSISHESPAVKLMKQSKTVDVLSRKLATKKKAISTKVMNSAVMRKTASSCPASLTCDCYATDKVCSICLSRRQQVAPRAGTPGFRAPEVLTKCPNQTTAIDMWSAGVIFLSLLSGRYPFYKASDDLTALAQIMTIRGSRETIQAAKTFGKSILCSKEVPAQDLRKLCERLRGMDSSTPKLTSDIQGHASHQPAISEKTDHKASCLVQTPPGQYSGNSFKKGDSNSCEHCFDEYNTNLEGWNEVPDEAYDLLDKLLDLNPASRITAEEALLHPFFKDMSL
  
Component 2
Name:
Protein DBF4 homolog A
Synonyms:
ASK | Activator of S phase kinase | Chiffon homolog A | DBF4 | DBF4-type zinc finger-containing protein 1 | DBF4A | DBF4A_HUMAN | Protein DBF4 homolog A | ZDBF1
Type:
Regulatory subunit
Mol. Mass.:
76869.65
Organism:
Homo sapiens (Human)
Description:
n/a
Residue:
674
Sequence:
MNSGAMRIHSKGHFQGGIQVKNEKNRPSLKSLKTDNRPEKSKCKPLWGKVFYLDLPSVTISEKLQKDIKDLGGRVEEFLSKDISYLISNKKEAKFAQTLGRISPVPSPESAYTAETTSPHPSHDGSSFKSPDTVCLSRGKLLVEKAIKDHDFIPSNSILSNALSWGVKILHIDDIRYYIEQKKKELYLLKKSSTSVRDGGKRVGSGAQKTRTGRLKKPFVKVEDMSQLYRPFYLQLTNMPFINYSIQKPCSPFDVDKPSSMQKQTQVKLRIQTDGDKYGGTSIQLQLKEKKKKGYCECCLQKYEDLETHLLSEQHRNFAQSNQYQVVDDIVSKLVFDFVEYEKDTPKKKRIKYSVGSLSPVSASVLKKTEQKEKVELQHISQKDCQEDDTTVKEQNFLYKETQETEKKLLFISEPIPHPSNELRGLNEKMSNKCSMLSTAEDDIRQNFTQLPLHKNKQECILDISEHTLSENDLEELRVDHYKCNIQASVHVSDFSTDNSGSQPKQKSDTVLFPAKDLKEKDLHSIFTHDSGLITINSSQEHLTVQAKAPFHTPPEEPNECDFKNMDSLPSGKIHRKVKIILGRNRKENLEPNAEFDKRTEFITQEENRICSSPVQSLLDLFQTSEEKSEFLGFTSYTEKSGICNVLDIWEEENSDNLLTAFFSSPSTSTFTGF
  
Inhibitor
Name:
BDBM27368
Synonyms:
2-(2-aminopyrimidin-4-yl)-7-(propan-2-yl)-1H,4H,5H,6H,7H-pyrrolo[3,2-c]pyridin-4-one | Pyrrolopyridinone, 87
Type:
Small organic molecule
Emp. Form.:
C14H17N5O
Mol. Mass.:
271.3177
SMILES:
CC(C)C1CNC(=O)c2cc([nH]c12)-c1ccnc(N)n1
Structure:
Search PDB for entries with ligand similarity:
Substrate
Name:
MCM2
Synonyms:
BM28 | CCNL1 | CDCL1 | DNA replication licensing factor MCM2 | KIAA0030 | MCM2 | MCM2_HUMAN | Minichromosome maintenance protein 2 homolog | Nuclear protein BM28
Type:
Other Protein Type
Mol. Mass.:
32619.37
Organism:
Homo sapiens (Human)
Description:
P49736[10-294]
Residue:
285
Sequence:
MASSPAQRRRGNDPLTSSPGRSSRRTDALTSSPGRDLPPFEDESEGLLGTEGPLEEEEDGEELIGDGMERDYRAIPELDAYEAEGLALDDEDVEELTASQREAAERAMRQRDREAGRGLGRMRRGLLYDSDEEDEERPARKRRQVERATEDGEEDEEMIESIENLEDLKGHSVREWVSMAGPRLEIHHRFKNFLRTHVDSHGHNVFKERISDMCKENRESLVVNYEDLAAREHVLAYFLPEAPAELLQIFDEAALEVVLAMYPKYDRITNHIHVRISHLPLVEEL