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Target
Signal transducer and activator of transcription 3 [127-722]
Ligand
BDBM28128
Substrate
Fluorescent-labeled peptide
Meas. Tech.
Fluorescence-Polarization (FP) Binding Assay
pH
7.5±n/a
Temperature
295.15±n/a K
Ki
350±150 nM
Citation
 Gomez, C; Bai, L; Zhang, J; Nikolovska-Coleska, Z; Chen, J; Yi, H; Wang, S Design, synthesis, and evaluation of peptidomimetics containing Freidinger lactams as STAT3 inhibitors. Bioorg Med Chem Lett 19:1733-6 (2009) [PubMed]  Article 
Target
Name:
Signal transducer and activator of transcription 3 [127-722]
Synonyms:
Acute-phase response factor | Aprf | STAT3 alpha | STAT3_MOUSE | Signal transducer and activator of transcription 3 | Stat3 | Transcription Factor STAT3
Type:
Cytosolic Transcription Factor
Mol. Mass.:
67962.98
Organism:
Mus musculus (mouse)
Description:
Purified recombinant STAT3 protein (residues 127-722).
Residue:
596
Sequence:
GQANHPTAAVVTEKQQMLEQHLQDVRKRVQDLEQKMKVVENLQDDFDFNYKTLKSQGDMQDLNGNNQSVTRQKMQQLEQMLTALDQMRRSIVSELAGLLSAMEYVQKTLTDEELADWKRRQQIACIGGPPNICLDRLENWITSLAESQLQTRQQIKKLEELQQKVSYKGDPIVQHRPMLEERIVELFRNLMKSAFVVERQPCMPMHPDRPLVIKTGVQFTTKVRLLVKFPELNYQLKIKVCIDKDSGDVAALRGSRKFNILGTNTKVMNMEESNNGSLSAEFKHLTLREQRCGNGGRANCDASLIVTEELHLITFETEVYHQGLKIDLETHSLPVVVISNICQMPNAWASILWYNMLTNNPKNVNFFTKPPIGTWDQVAEVLSWQFSSTTKRGLSIEQLTTLAEKLLGPGVNYSGCQITWAKFCKENMAGKGFSFWVWLDNIIDLVKKYILALWNEGYIMGFISKERERAILSTKPPGTFLLRFSESSKEGGVTFTWVEKDISGKTQIQSVEPYTKQQLNNMSFAEIIMGYKIMDATNILVSPLVYLYPDIPKEEAFGKYCRPESQEHPEADPGSAAPYLKTKFICVTPTTCSNTI
  
Inhibitor
Name:
BDBM28128
Synonyms:
4-[(2S)-2-{[(2S)-1-[(2S)-2-{[(1S)-1-(benzylcarbamoyl)-3-carbamoylpropyl]carbamoyl}pyrrolidin-1-yl]-4-methyl-1-oxopentan-2-yl]carbamoyl}-2-{[(benzyloxy)carbonyl]amino}ethyl]phenoxyphosphonic acid | shortened gp130 peptidomimetic, 1
Type:
Small organic molecule
Emp. Form.:
C40H51N6O11P
Mol. Mass.:
822.8403
SMILES:
CC(C)C[C@H](NC(=O)[C@H](Cc1ccc(OP(O)(O)=O)cc1)NC(=O)OCc1ccccc1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(N)=O)C(=O)NCc1ccccc1 |r|
Structure:
Search PDB for entries with ligand similarity:
Substrate
Name:
Fluorescent-labeled peptide
Synonyms:
5-carboxyfluorescein (5-FAM)-labeled peptide
Type:
Peptide
Mol. Mass.:
2334.64
Organism:
n/a
Description:
n/a
Residue:
23
Sequence:
FAMETAALAETAALAGPYLPQTV