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TargetADAMTS-5 (Aggrecanase-2)
LigandBDBM28308
Substrate/CompetitorWAAG-3R
Meas. Tech.ADAMTS-5 Enzyme Inhibition Assay
pH7.5±n/a
Temperature310.15±n/a K
Comments-0.12% inhibition @ 10 uM.
Citation Shiozaki, MMaeda, KMiura, TOgoshi, YHaas, JFryer, AMLaird, ERLittmann, NMAndrews, SWJosey, JAMimura, TShinozaki, YYoshiuchi, HInaba, T Novel N-substituted 2-phenyl-1-sulfonylamino-cyclopropane carboxylates as selective ADAMTS-5 (Aggrecanase-2) inhibitors. Bioorg Med Chem Lett19:1575-80 (2009) [PubMed]  Article
More Info.:Get all data from this article,  Inhibition_Run data,   Solution Info,  Assay Method
 
ADAMTS-5 (Aggrecanase-2)
Name:ADAMTS-5 (Aggrecanase-2)
Synonyms:A disintegrin and metalloproteinase with thrombospondin motifs 5 | ADAM-TS 11 | ADMP-2
Type:Metalloprotease
Mol. Mass.:73728.14
Organism:Homo sapiens (human)
Description:n/a
Residue:669
Sequence:
SISRARQVELLLVADASMARLYGRGLQHYLLTLASIANRLYSHASIENHIRLAVVKVVVL
GDKDKSLEVSKNAATTLKNFCKWQHQHNQLGDDHEEHYDAAILFTREDLCGHHSCDTLGM
ADVGTICSPERSCAVIEDDGLHAAFTVAHEIGHLLGLSHDDSKFCEETFGSTEDKRLMSS
ILTSIDASKPWSKCTSATITEFLDDGHGNCLLDLPRKQILGPEELPGQTYDATQQCNLTF
GPEYSVCPGMDVCARLWCAVVRQGQMVCLTKKLPAVEGTPCGKGRICLQGKCVDKTKKKY
YSTSSHGNWGSWGSWGQCSRSCGGGVQFAYRHCNNPAPRNNGRYCTGKRAIYRSCSLMPC
PPNGKSFRHEQCEAKNGYQSDAKGVKTFVEWVPKYAGVLPADVCKLTCRAKGTGYYVVFS
PKVTDGTECRPYSNSVCVRGKCVRTGCDGIIGSKLQYDKCGVCGGDNSSCTKIVGTFNKK
SKGYTDVVRIPEGATHIKVRQFKAKDQTRFTAYLALKKKNGEYLINGKYMISTSETIIDI
NGTVMNYSGWSHRDDFLHGMGYSATKEILIVQILATDPTKPLDVRYSFFVPKKSTPKVNS
VTSHGSNKVGSHTSQPQWVTGPWLACSRTCDTGWHTRTVQCQDGNRKLAKGCPLSQRPSA
FKQCLLKKC
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM28308
WAAG-3R
Name:WAAG-3R
Synonyms:n/a
Type:Fluorescent peptide
Mol. Mass.:1954.08
Organism:n/a
Description:n/a
Residue:19
Sequence:
Abz-TEGEARGSVI-Dap(Dnp)-KK