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Target
Serine/threonine-protein kinase pim-2
Ligand
BDBM28404
Substrate
PIM peptide substrate
Meas. Tech.
Pim Kinase Dose-Response Assay
pH
7.5±n/a
Temperature
295.15±n/a K
IC50
10±0.4 nM
Citation
 Qian, K; Wang, L; Cywin, CL; Farmer, BT; Hickey, E; Homon, C; Jakes, S; Kashem, MA; Lee, G; Leonard, S; Li, J; Magboo, R; Mao, W; Pack, E; Peng, C; Prokopowicz, A; Welzel, M; Wolak, J; Morwick, T Hit to lead account of the discovery of a new class of inhibitors of Pim kinases and crystallographic studies revealing an unusual kinase binding mode. J Med Chem 52:1814-27 (2009) [PubMed]  Article 
Target
Name:
Serine/threonine-protein kinase pim-2
Synonyms:
PIM2 | PIM2_HUMAN | Pim-2h | Serine/threonine-protein kinase (PIM2) | Serine/threonine-protein kinase PIM | Serine/threonine-protein kinase pim-2 (PIM2)
Type:
Serine/threonine-protein kinase
Mol. Mass.:
34185.93
Organism:
Homo sapiens (Human)
Description:
Q9P1W9
Residue:
311
Sequence:
MLTKPLQGPPAPPGTPTPPPGGKDREAFEAEYRLGPLLGKGGFGTVFAGHRLTDRLQVAIKVIPRNRVLGWSPLSDSVTCPLEVALLWKVGAGGGHPGVIRLLDWFETQEGFMLVLERPLPAQDLFDYITEKGPLGEGPSRCFFGQVVAAIQHCHSRGVVHRDIKDENILIDLRRGCAKLIDFGSGALLHDEPYTDFDGTRVYSPPEWISRHQYHALPATVWSLGILLYDMVCGDIPFERDQEILEAELHFPAHVSPDCCALIRRCLAPKPSSRPSLEEILLDPWMQTPAEDVPLNPSKGGPAPLAWSLLP
  
Inhibitor
Name:
BDBM28404
Synonyms:
(2E)-3-{3-[6-(1,4-diazepan-1-yl)pyrazin-2-yl]phenyl}prop-2-enoic acid | pyrazine inhibitor, 7
Type:
Small organic molecule
Emp. Form.:
C18H20N4O2
Mol. Mass.:
324.377
SMILES:
OC(=O)\C=C\c1cccc(c1)-c1cncc(n1)N1CCCNCC1
Structure:
Search PDB for entries with ligand similarity:
Substrate
Name:
PIM peptide substrate
Synonyms:
n/a
Type:
Biotinylated peptide
Mol. Mass.:
1402.69
Organism:
n/a
Description:
n/a
Residue:
12
Sequence:
ITINAKRRRLSA