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Reaction Details
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TargetHIV-1 Protease
LigandBDBM421
Substrate/CompetitorPeptide substrate
Meas. Tech.Protease Inhibition Assay
pH6.2±n/a
Temperature310.15±n/a K
Ki 0.83±n/a nM
Citation Boyer, FEVara Prasad, JVDomagala, JMEllsworth, ELGajda, CHagen, SEMarkoski, LJTait, BDLunney, EAPalovsky, AFerguson, DGraham, NHoller, THupe, DNouhan, CTummino, PJUrumov, AZeikus, EZeikus, GGracheck, SJSanders, JMVanderRoest, SBrodfuehrer, JIyer, KSinz, MGulnik, SV 5,6-Dihydropyran-2-ones possessing various sulfonyl functionalities: potent nonpeptidic inhibitors of HIV protease. J Med Chem43:843-58 (2000) [PubMed]  Article
More Info.:Get all data from this article,  Inhibition_Run data,   Solution Info,  Assay Method
 
HIV-1 Protease
Name:HIV-1 Protease
Synonyms:n/a
Type:Protein Complex
Mol. Mass.:n/a
Description:n/a
Components:This complex has 2 components.
Component 1
Name:HIV-1 Protease chain A
Synonyms:HIV protease
Type:Enzyme Subunit
Mol. Mass.:358.43
Organism:Human immunodeficiency virus type 1
Description:n/a
Residue:3
Sequence:
n/a
 
Component 2
Name:HIV-1 Protease chain B
Synonyms:n/a
Type:Enzyme Subunit
Mol. Mass.:358.43
Organism:Human immunodeficiency virus type 1
Description:n/a
Residue:3
Sequence:
n/a
 
BDBM421
NameBDBM421
Synonyms:CHEMBL169849 | Dihydropyran-2-one deriv. 26 | N-(5-tert-butyl-4-{[4-hydroxy-2-oxo-6-(2-phenylethyl)-6-(propan-2-yl)-5,6-dihydro-2H-pyran-3-yl]sulfanyl}-2-methylphenyl)methanesulfonamide
TypeSmall organic molecule
Emp. Form.n/a
Mol. Mass.n/a
SMILESn/a
Structure 
Peptide substrate
Name:Peptide substrate
Synonyms:n/a
Type:Peptide
Mol. Mass.:3763.66
Organism:n/a
Description:n/a
Residue:35
Sequence:
His-Lys-Ala-Arg-Val-Leu-(p-NO2-Phe)-Glu-Ala-Nle-Ser-NH2