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Target
Caspase-8
Ligand
BDBM29578
Substrate
Caspase-8 Substrate
Meas. Tech.
Enzyme Inhibition Assay
pH
7.4±n/a
Temperature
310.15±n/a K
IC50
>50000±n/a nM
Citation
 Chu, W; Rothfuss, J; Chu, Y; Zhou, D; Mach, RH Synthesis and in vitro evaluation of sulfonamide isatin Michael acceptors as small molecule inhibitors of caspase-6. J Med Chem 52:2188-91 (2009) [PubMed]  Article 
Target
Name:
Caspase-8
Synonyms:
Apoptotic cysteine protease | Apoptotic protease Mch-5 | CAP4 | CASP-8 | CASP8 | CASP8_HUMAN | Caspase | Caspase-8 subunit p10 | Caspase-8 subunit p18 | FADD-homologous ICE/CED-3-like protease | FADD-like ICE | FLICE | ICE-like apoptotic protease 5 | MACH | MCH5 | MORT1-associated CED-3 homolog
Type:
Enzyme
Mol. Mass.:
55373.89
Organism:
Homo sapiens (Human)
Description:
Q14790
Residue:
479
Sequence:
MDFSRNLYDIGEQLDSEDLASLKFLSLDYIPQRKQEPIKDALMLFQRLQEKRMLEESNLSFLKELLFRINRLDLLITYLNTRKEEMERELQTPGRAQISAYRVMLYQISEEVSRSELRSFKFLLQEEISKCKLDDDMNLLDIFIEMEKRVILGEGKLDILKRVCAQINKSLLKIINDYEEFSKERSSSLEGSPDEFSNGEELCGVMTISDSPREQDSESQTLDKVYQMKSKPRGYCLIINNHNFAKAREKVPKLHSIRDRNGTHLDAGALTTTFEELHFEIKPHDDCTVEQIYEILKIYQLMDHSNMDCFICCILSHGDKGIIYGTDGQEAPIYELTSQFTGLKCPSLAGKPKVFFIQACQGDNYQKGIPVETDSEEQPYLEMDLSSPQTRYIPDEADFLLGMATVNNCVSYRNPAEGTWYIQSLCQSLRERCPRGDDILTILTEVNYEVSNKDDKKNMGKQMPQPTFTLRKKLVFPSD
  
Inhibitor
Name:
BDBM29578
Synonyms:
isatin Michael acceptor (IMA) analogue, 13a
Type:
Small organic molecule
Emp. Form.:
C22H18N4O3S2
Mol. Mass.:
450.533
SMILES:
O=[#6]1-[#7](-[#6]-c2ccccc2)-c2ccc(cc2\[#6]-1=[#6](/C#N)C#N)S(=O)(=O)[#7]-1-[#6]-[#6]-[#16]-[#6]-[#6]-1
Structure:
Search PDB for entries with ligand similarity:
Substrate
Name:
Caspase-8 Substrate
Synonyms:
N-Acetyl-Ile-Glu-Thr-Asp-7-Amido-4-methylcoumarin
Type:
Fluorogenic Substrate
Mol. Mass.:
954.10
Organism:
n/a
Description:
n/a
Residue:
9
Sequence:
ACIETDAMC