Reaction Details Report a problem with these data
Target
Caspase-6
Ligand
BDBM29572
Substrate
Caspase-6 Substrate
Meas. Tech.
Enzyme Inhibition Assay
IC50
325±n/a nM
Citation
 Chu, W; Rothfuss, J; Chu, Y; Zhou, D; Mach, RH Synthesis and in vitro evaluation of sulfonamide isatin Michael acceptors as small molecule inhibitors of caspase-6. J Med Chem 52:2188-91 (2009) [PubMed]  Article 
Target
Name:
Caspase-6
Synonyms:
Apoptotic protease Mch-2 | CASP-6 | CASP6 | CASP6_HUMAN | Caspase | MCH2
Type:
Enzyme
Mol. Mass.:
33312.62
Organism:
Homo sapiens (Human)
Description:
P55212
Residue:
293
Sequence:
MSSASGLRRGHPAGGEENMTETDAFYKREMFDPAEKYKMDHRRRGIALIFNHERFFWHLTLPERRGTCADRDNLTRRFSDLGFEVKCFNDLKAEELLLKIHEVSTVSHADADCFVCVFLSHGEGNHIYAYDAKIEIQTLTGLFKGDKCHSLVGKPKIFIIQACRGNQHDVPVIPLDVVDNQTEKLDTNITEVDAASVYTLPAGADFLMCYSVAEGYYSHRETVNGSWYIQDLCEMLGKYGSSLEFTELLTLVNRKVSQRRVDFCKDPSAIGKKQVPCFASMLTKKLHFFPKSN
  
Inhibitor
Name:
BDBM29572
Synonyms:
isatin Michael acceptor (IMA) analogue, 11a
Type:
Small organic molecule
Emp. Form.:
C23H20N4O3S
Mol. Mass.:
432.495
SMILES:
O=[#6]1-[#7](-[#6]-c2ccccc2)-c2ccc(cc2\[#6]-1=[#6](/C#N)C#N)S(=O)(=O)[#7]-1-[#6]-[#6]-[#6]-[#6]-[#6]-1
Structure:
Search PDB for entries with ligand similarity:
Substrate
Name:
Caspase-6 Substrate
Synonyms:
N-Acetyl-Val-Glu-Ile-Asp-7-amido-4-methylcoumarin
Type:
Fluorogenic Substrate
Mol. Mass.:
952.13
Organism:
n/a
Description:
n/a
Residue:
9
Sequence:
ACVEIDAMC