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TargetCaspase-7
LigandBDBM10246
Substrate/CompetitorCaspase-7 Substrate
Meas. Tech.Enzyme Inhibition Assay
IC50 2.95±n/a nM
Citation Chu, WRothfuss, JChu, YZhou, DMach, RH Synthesis and in vitro evaluation of sulfonamide isatin Michael acceptors as small molecule inhibitors of caspase-6. J Med Chem52:2188-91 (2009) [PubMed]  Article
More Info.:Get all data from this article,   Solution Info,  Assay Method
 
Caspase-7
Name:Caspase
Synonyms:Apoptotic protease Mch-3 | CASP-7 | CMH-1 | caspase 7, apoptosis-related cysteine peptidase
Type:Enzyme
Mol. Mass.:34273.91
Organism:Homo sapiens (human)
Description:P55210
Residue:303
Sequence:
MADDQGCIEEQGVEDSANEDSVDAKPDRSSFVPSLFSKKKKNVTMRSIKTTRDRVPTYQY
NMNFEKLGKCIIINNKNFDKVTGMGVRNGTDKDAEALFKCFRSLGFDVIVYNDCSCAKMQ
DLLKKASEEDHTNAACFACILLSHGEENVIYGKDGVTPIKDLTAHFRGDRCKTLLEKPKL
FFIQACRGTELDDGIQADSGPINDTDANPRYKIPVEADFLFAYSTVPGYYSWRSPGRGSW
FVQALCSILEEHGKDLEIMQILTRVNDRVARHFESQSDDPHFHEKKQIPCVVSMLTKELY
FSQ
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  Blast E-value cutoff:
BDBM10246
NameBDBM10246
Synonyms:(4S)-4-{[(1S)-1-{[(2S)-1-carboxy-3-oxopropan-2-yl]carbamoyl}-2-methylpropyl]carbamoyl}-4-[(3S)-3-acetamido-3-formamidopropanoic acid]butanoic acid | Ac-DEVD-CHO | CHEMBL417149
TypeSmall organic molecule
Emp. Form.C20H30N4O11
Mol. Mass.502.4724
SMILESCC(C)[C@H](NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CC(O)=O)NC(C)=O)C(=O)N[C@@H](CC(O)=O)C=O |r|
Structure
Search PDB for entries with ligand similarity:Similarity to this molecule at least:
Caspase-7 Substrate
Name:Caspase-7 Substrate
Synonyms:N-Acetyl-Asp-Glu-Val-Asp-7-amido-4-methylcoumarin
Type:Fluorogenic Substrate
Mol. Mass.:953.05
Organism:n/a
Description:n/a
Residue:9
Sequence:
Ac-DEVD-AMC