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TargetRunt-Related Transcription Factor 1 Isoform AML1C
LigandBDBM29672
Substrate/CompetitorVenus-CBFbeta-SMMHC
Meas. Tech.uHTS identification of compounds inhibiting the binding between the RUNX1 Runt domain and CBFb-SMMHC via a fluorescence resonance energy transfer (FRET) assay.
pH7.4±n/a
Temperature296.15±n/a K
IC50 7940±n/a nM
Citation PubChem, PC uHTS identification of compounds inhibiting the binding between the RUNX1 Runt domain and CBFbeta-SMMHC via a fluorescence resonance energy transfer (FRET) assay. PubChem Bioassay(2009)[AID]
More Info.:Get all data from this article,   Solution Info,  Assay Method
 
Runt-Related Transcription Factor 1 Isoform AML1C
Name:Runt-Related Transcription Factor 1 Isoform AML1C
Synonyms:Acute myeloid leukemia 1 protein | CBF-alpha-2 | Core-binding factor subunit alpha-2 | Oncogene AML-1 | Polyomavirus enhancer-binding protein 2 alpha B subunit
Type:Subunit of heterodimeric transcription factor
Mol. Mass.:48750.25
Organism:Homo sapiens (Human)
Description:Q01196
Residue:453
Sequence:
MRIPVDASTSRRFTPPSTALSPGKMSEALPLGAPDAGAALAGKLRSGDRSMVEVLADHPG
ELVRTDSPNFLCSVLPTHWRCNKTLPIAFKVVALGDVPDGTLVTVMAGNDENYSAELRNA
TAAMKNQVARFNDLRFVGRSGRGKSFTLTITVFTNPPQVATYHRAIKITVDGPREPRRHR
QKLDDQTKPGSLSFSERLSELEQLRRTAMRVSPHHPAPTPNPRASLNHSTAFNPQPQSQM
QDTRQIQPSPPWSYDQSYQYLGSIASPSVHPATPISPGRASGMTTLSAELSSRLSTAPDL
TAFSDPRQFPALPSISDPRMHYPGAFTYSPTPVTSGIGIGMSAMGSATRYHTYLPPPYPG
SSQAQGGPFQASSPSYHLYYGASAGSYQFSMVGGERSPPRILPPCTNASTGSALLNPSLP
NQSDVVEAEGSHSNSPTNMAPSARLEEAVWRPY
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BDBM29672
NameBDBM29672
Synonyms:5-(2-keto-7-methoxy-4-propionyloxy-6-propyl-chromen-3-yl)furan-2-carboxylic acid ethyl ester | 5-(7-Methoxy-2-oxo-4-propionyloxy-6-propyl-2H-chromen-3-yl)-furan-2-carboxylic acid ethyl ester | 5-[7-methoxy-2-oxo-4-(1-oxopropoxy)-6-propyl-1-benzopyran-3-yl]-2-furancarboxylic acid ethyl ester | MLS000590498 | SMR000217534 | cid_1547789 | ethyl 5-(7-methoxy-2-oxidanylidene-4-propanoyloxy-6-propyl-chromen-3-yl)furan-2-carboxylate | ethyl 5-(7-methoxy-2-oxo-4-propanoyloxy-6-propylchromen-3-yl)furan-2-carboxylate
TypeSmall organic molecule
Emp. Form.C23H24O8
Mol. Mass.428.4319
SMILESCCCc1cc2c(OC(=O)CC)c(-c3ccc(o3)C(=O)OCC)c(=O)oc2cc1OC
Structure
Search PDB for entries with ligand similarity:Similarity to this molecule at least:
Venus-CBFbeta-SMMHC
Name:Venus-CBFbeta-SMMHC
Synonyms:CBFbeta | Core-binding factor subunit beta isoform 2 | Venus-core-binding factor subunit beta-smooth muscle myosin heavy chain
Type:Fluorescent fusion protein
Mol. Mass.:21988.19
Organism:Homo sapiens (Human)
Description:Venus-CBFbeta-SMMHC was provided by Dr. John Bushweller (University of Virginia Charlottesville, Charlottesville VA). Only the amino acid sequence of core-binding factor subunit beta (CBFbeta) isoform 2 is shown here.
Residue:187
Sequence:
MPRVVPDQRSKFENEEFFRKLSRECEIKYTGFRDRPHEERQARFQNACRDGRSEIAFVAT
GTNLSLQFFPASWQGEQRQTPSREYVDLEREAGKVYLKAPMILNGVCVIWKGWIDLQRLD
GMGCLEFDEERAQQEDALAQQAFEEARRRTREFEDRDRSHREEMEARRQQDPSPGSNLGG
GDDLKLR
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