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TargetRunt-Related Transcription Factor 1 Isoform AML1C
LigandBDBM29652
Substrate/CompetitorVenus-CBFbeta-SMMHC
Meas. Tech.Confirmation of compounds inhibiting the binding between the RUNX1 Runt domain and CBFb-SMMHC via a fluorescence resonance energy transfer (FRET) assay
pH7.4±n/a
Temperature296.15±n/a K
IC50 1865.2±n/a nM
Citation PubChem, PC Confirmation of compounds inhibiting the binding between the RUNX1 Runt domain and CBFb-SMMHC via a fluorescence resonance energy transfer (FRET) assay PubChem Bioassay(2009)[AID]
More Info.:Get all data from this article,   Solution Info,  Assay Method
 
Runt-Related Transcription Factor 1 Isoform AML1C
Name:Runt-Related Transcription Factor 1 Isoform AML1C
Synonyms:Acute myeloid leukemia 1 protein | CBF-alpha-2 | Core-binding factor subunit alpha-2 | Oncogene AML-1 | Polyomavirus enhancer-binding protein 2 alpha B subunit
Type:Subunit of heterodimeric transcription factor
Mol. Mass.:48750.25
Organism:Homo sapiens (Human)
Description:Q01196
Residue:453
Sequence:
MRIPVDASTSRRFTPPSTALSPGKMSEALPLGAPDAGAALAGKLRSGDRSMVEVLADHPG
ELVRTDSPNFLCSVLPTHWRCNKTLPIAFKVVALGDVPDGTLVTVMAGNDENYSAELRNA
TAAMKNQVARFNDLRFVGRSGRGKSFTLTITVFTNPPQVATYHRAIKITVDGPREPRRHR
QKLDDQTKPGSLSFSERLSELEQLRRTAMRVSPHHPAPTPNPRASLNHSTAFNPQPQSQM
QDTRQIQPSPPWSYDQSYQYLGSIASPSVHPATPISPGRASGMTTLSAELSSRLSTAPDL
TAFSDPRQFPALPSISDPRMHYPGAFTYSPTPVTSGIGIGMSAMGSATRYHTYLPPPYPG
SSQAQGGPFQASSPSYHLYYGASAGSYQFSMVGGERSPPRILPPCTNASTGSALLNPSLP
NQSDVVEAEGSHSNSPTNMAPSARLEEAVWRPY
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BDBM29652
NameBDBM29652
Synonyms:5-chloranyl-N-[4-([1,3]thiazolo[5,4-b]pyridin-2-yl)phenyl]thiophene-2-sulfonamide | 5-chloro-N-(4-thiazolo[5,4-b]pyridin-2-ylphenyl)thiophene-2-sulfonamide | 5-chloro-N-[4-(2-thiazolo[5,4-b]pyridinyl)phenyl]-2-thiophenesulfonamide | 5-chloro-N-[4-([1,3]thiazolo[5,4-b]pyridin-2-yl)phenyl]thiophene-2-sulfonamide | MLS000529654 | SMR000127208 | cid_9550485
TypeSmall organic molecule
Emp. Form.C16H10ClN3O2S3
Mol. Mass.407.918
SMILESClc1ccc(s1)S(=O)(=O)Nc1ccc(cc1)-c1nc2cccnc2s1
Structure
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Venus-CBFbeta-SMMHC
Name:Venus-CBFbeta-SMMHC
Synonyms:CBFbeta | Core-binding factor subunit beta isoform 2 | Venus-core-binding factor subunit beta-smooth muscle myosin heavy chain
Type:Fluorescent fusion protein
Mol. Mass.:21988.19
Organism:Homo sapiens (Human)
Description:Venus-CBFbeta-SMMHC was provided by Dr. John Bushweller (University of Virginia Charlottesville, Charlottesville VA). Only the amino acid sequence of core-binding factor subunit beta (CBFbeta) isoform 2 is shown here.
Residue:187
Sequence:
MPRVVPDQRSKFENEEFFRKLSRECEIKYTGFRDRPHEERQARFQNACRDGRSEIAFVAT
GTNLSLQFFPASWQGEQRQTPSREYVDLEREAGKVYLKAPMILNGVCVIWKGWIDLQRLD
GMGCLEFDEERAQQEDALAQQAFEEARRRTREFEDRDRSHREEMEARRQQDPSPGSNLGG
GDDLKLR
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