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Target
Cathepsin B
Ligand
BDBM31982
Substrate
BDBM31994
Meas. Tech.
Cathepsin Inhibition Assay
IC50
>10000±n/a nM
Citation
 Asaad, N; Bethel, PA; Coulson, MD; Dawson, JE; Ford, SJ; Gerhardt, S; Grist, M; Hamlin, GA; James, MJ; Jones, EV; Karoutchi, GI; Kenny, PW; Morley, AD; Oldham, K; Rankine, N; Ryan, D; Wells, SL; Wood, L; Augustin, M; Krapp, S; Simader, H; Steinbacher, S Dipeptidyl nitrile inhibitors of Cathepsin L. Bioorg Med Chem Lett 19:4280-3 (2009) [PubMed]  Article 
Target
Name:
Cathepsin B
Synonyms:
APP secretase | APPS | CATB_HUMAN | CPSB | CTSB | Cathepsin B heavy chain | Cathepsin B light chain | Cathepsin B1
Type:
Enzyme
Mol. Mass.:
37819.69
Organism:
Homo sapiens (Human)
Description:
gi_63102437
Residue:
339
Sequence:
MWQLWASLCCLLVLANARSRPSFHPLSDELVNYVNKRNTTWQAGHNFYNVDMSYLKRLCGTFLGGPKPPQRVMFTEDLKLPASFDAREQWPQCPTIKEIRDQGSCGSCWAFGAVEAISDRICIHTNAHVSVEVSAEDLLTCCGSMCGDGCNGGYPAEAWNFWTRKGLVSGGLYESHVGCRPYSIPPCEHHVNGSRPPCTGEGDTPKCSKICEPGYSPTYKQDKHYGYNSYSVSNSEKDIMAEIYKNGPVEGAFSVYSDFLLYKSGVYQHVTGEMMGGHAIRILGWGVENGTPYWLVANSWNTDWGDNGFFKILRGQDHCGIESEVVAGIPRTDQYWEKI
  
Inhibitor
Name:
BDBM31982
Synonyms:
Dipeptidyl nitrile inhibitor, 15
Type:
Small organic molecule
Emp. Form.:
C22H22ClN3O2
Mol. Mass.:
395.882
SMILES:
Clc1cccc(C[C@H](NC(=O)c2cccc3CCCCc23)C(=O)NCC#N)c1 |r|
Structure:
Search PDB for entries with ligand similarity:
Substrate
Name:
BDBM31994
Synonyms:
Benzyloxycarbonylarginyl-arginine 4-methylcoumarin-7-ylamide | Z-Arg-Arg-AMC
Type:
n/a
Emp. Form.:
C30H39N9O6
Mol. Mass.:
621.6874
SMILES:
[#6]-c1cc(=O)oc2cc(-[#7]-[#6](=O)-[#6](-[#6]-[#6]-[#6]\[#7]=[#6](\[#7])-[#7])-[#7]-[#6](=O)-[#6](-[#6]-[#6]-[#6]\[#7]=[#6](\[#7])-[#7])-[#7]-[#6](=O)-[#8]-[#6]-c3ccccc3)ccc12
Structure:
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