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Target
Isoform Bcl-X(L) of Bcl-2-like protein 1 (Bcl-xL)
Ligand
BDBM32300
Substrate
F-Bim
Meas. Tech.
Multiplexed dose response screen for small molecule regulators of Bcl-2 family protein interactions, specifically Bim-Bcl-XL.
pH
7.4±n/a
Temperature
277.15±n/a K
EC50
10090±n/a nM
Citation
 PubChem, PC Multiplexed dose response screen for small molecule regulators of Bcl-2 family protein interactions, specifically Bim-Bcl-XL. PubChem Bioassay (2008)[AID] 
Target
Name:
Isoform Bcl-X(L) of Bcl-2-like protein 1 (Bcl-xL)
Synonyms:
B-cell lymphoma-extra large protein (Bcl-xL) | B2CL1_HUMAN | BCL-xL | BCL2L | BCL2L1 | BCLX | Bcl-2-like protein 1 (Bcl-xL) | Isoform Bcl-X(L)
Type:
Homodimers/heterodimers with BAX, BAK and BCL2
Mol. Mass.:
26053.63
Organism:
Homo sapiens (Human)
Description:
gi_510901
Residue:
233
Sequence:
MSQSNRELVVDFLSYKLSQKGYSWSQFSDVEENRTEAPEGTESEMETPSAINGNPSWHLADSPAVNGATAHSSSLDAREVIPMAAVKQALREAGDEFELRYRRAFSDLTSQLHITPGTAYQSFEQVVNELFRDGVNWGRIVAFFSFGGALCVESVDKEMQVLVSRIAAWMATYLNDHLEPWIQENGGWDTFVELYGNNAAAESRKGQERFNRWFLTGMTVAGVVLLGSLFSRK
  
Inhibitor
Name:
BDBM32300
Synonyms:
4-(2-methyl-3-imidazo[1,2-a]pyrimidinyl)-N-phenyl-2-thiazolamine | 4-(2-methylimidazo[1,2-a]pyrimidin-3-yl)-N-phenyl-1,3-thiazol-2-amine | MLS000585233 | SMR000203996 | [4-(2-methylimidazo[1,2-a]pyrimidin-3-yl)thiazol-2-yl]-phenyl-amine | cid_697303
Type:
Small organic molecule
Emp. Form.:
C16H13N5S
Mol. Mass.:
307.373
SMILES:
Cc1nc2ncccn2c1-c1csc(Nc2ccccc2)n1
Structure:
Search PDB for entries with ligand similarity:
Substrate
Name:
F-Bim
Synonyms:
n/a
Type:
fluorescent peptide probe
Mol. Mass.:
3923.40
Organism:
n/a
Description:
n/a
Residue:
32
Sequence:
FITCAHDMRPEIWIAQELRRIGDEFNAYYARH