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Target
Baculoviral IAP repeat-containing protein 2 [269-336]
Ligand
BDBM32576
Substrate
BDBM17342
Meas. Tech.
Fluorescence Polarization Affinity Measurements
pH
7.2±n/a
Temperature
295.15±n/a K
Ki
36±n/a nM
Citation
 Ndubaku, C; Varfolomeev, E; Wang, L; Zobel, K; Lau, K; Elliott, LO; Maurer, B; Fedorova, AV; Dynek, JN; Koehler, M; Hymowitz, SG; Tsui, V; Deshayes, K; Fairbrother, WJ; Flygare, JA; Vucic, D Antagonism of c-IAP and XIAP proteins is required for efficient induction of cell death by small-molecule IAP antagonists. ACS Chem Biol 4:557-66 (2009) [PubMed]  Article 
Target
Name:
Baculoviral IAP repeat-containing protein 2 [269-336]
Synonyms:
API1 | BIRC2 | BIRC2_HUMAN | Baculoviral IAP repeat-containing protein 2 | IAP homolog B | Inhibitor of apoptosis protein 2 | MIHB | RNF48 | cIAP-1 BIR3
Type:
BIR3 domain
Mol. Mass.:
7949.91
Organism:
Homo sapiens (Human)
Description:
Q13490[269-336]
Residue:
68
Sequence:
HAARMRTFMYWPSSVPVQPEQLASAGFYYVGRNDDVKCFCCDGGLRCWESGDDPWVEHAKWFPRCEFL
  
Inhibitor
Name:
BDBM32576
Synonyms:
PS-1
Type:
Small organic molecule
Emp. Form.:
C27H32ClN5O3S
Mol. Mass.:
542.093
SMILES:
CN[C@@H](C)C(=O)N[C@@H](C1CCOCC1)C(=O)N1CCC[C@H]1c1nc2c(nccc2s1)-c1ccccc1Cl |r|
Structure:
Search PDB for entries with ligand similarity:
Substrate
Name:
BDBM17342
Synonyms:
5-carboxyflourescein(5-FAM)-conjugated AVPFFAKK | AVP-diPhe-FAM
Type:
Fluorescent dye-conjugated peptide
Emp. Form.:
n/a
Mol. Mass.:
n/a
SMILES:
n/a
Structure: