Reaction Details Report a problem with these data
Target
Bcl-2-related protein A1
Ligand
BDBM32319
Substrate
FITC-conjugated-Bim BH3 Peptide
Meas. Tech.
Multiplexed dose response screen for small molecule regulators of Bcl-2 family protein interactions, specifically Bim-Bfl-1.
pH
7.4±n/a
Temperature
277.15±n/a K
EC50
19950±n/a nM
Citation
 PubChem, PC Multiplexed dose response screen for small molecule regulators of Bcl-2 family protein interactions, specifically Bim-Bfl-1. PubChem Bioassay (2008)[AID] 
Target
Name:
Bcl-2-related protein A1
Synonyms:
B2LA1_HUMAN | BCL2A1 | BCL2L5 | BFL1 | Bcl-2-like protein 5 | GRS | HBPA1 | Hemopoietic-specific early response protein | Protein BFL-1 | Protein GRS
Type:
Apoptosis regulator protein
Mol. Mass.:
20130.01
Organism:
Homo sapiens (Human)
Description:
n/a
Residue:
175
Sequence:
MTDCEFGYIYRLAQDYLQCVLQIPQPGSGPSKTSRVLQNVAFSVQKEVEKNLKSCLDNVNVVSVDTARTLFNQVMEKEFEDGIINWGRIVTIFAFEGILIKKLLRQQIAPDVDTYKEISYFVAEFIMNNTGEWIRQNGGWENGFVKKFEPKSGWMTFLEVTGKICEMLSLLKQYC
  
Inhibitor
Name:
BDBM32319
Synonyms:
(5Z)-2-morpholino-5-[[5-(p-tolyl)-2-furyl]methylene]-2-thiazolin-4-one | (5Z)-5-[[5-(4-methylphenyl)-2-furanyl]methylidene]-2-(4-morpholinyl)-4-thiazolone | (5Z)-5-[[5-(4-methylphenyl)furan-2-yl]methylidene]-2-morpholin-4-yl-1,3-thiazol-4-one | 2-Morpholin-4-yl-5-(5-p-tolyl-furan-2-ylmethylene)-thiazol-4-one | MLS000723666 | SMR000305261 | cid_1115796
Type:
Small organic molecule
Emp. Form.:
C19H18N2O3S
Mol. Mass.:
354.423
SMILES:
Cc1ccc(cc1)-c1ccc(\C=C2/SC(=NC2=O)N2CCOCC2)o1 |c:15|
Structure:
Search PDB for entries with ligand similarity:
Substrate
Name:
FITC-conjugated-Bim BH3 Peptide
Synonyms:
FITC-Ahx-DMRPEIWIAQELRRIGDEFNAYYAR-OH
Type:
FITC-labeled Peptide
Mol. Mass.:
3112.46
Organism:
n/a
Description:
n/a
Residue:
25
Sequence:
DMRPEIWIAQELRRIGDEFNAYYAR