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Target
Casein kinase II subunit alpha
Ligand
BDBM34044
Substrate
CK-2 Peptide Substrate
Meas. Tech.
CK2 Phosphorylation Assay
pH
7.5±n/a
Temperature
310.15±n/a K
Ki
24±n/a nM
Citation
 Gianoncelli, A; Cozza, G; Orzeszko, A; Meggio, F; Kazimierczuk, Z; Pinna, LA Tetraiodobenzimidazoles are potent inhibitors of protein kinase CK2. Bioorg Med Chem 17:7281-9 (2009) [PubMed]  Article 
Target
Name:
Casein kinase II subunit alpha
Synonyms:
CSK21_RAT | Casein Kinase II | Csnk2a1
Type:
Enzyme Subunit
Mol. Mass.:
45081.00
Organism:
Rattus norvegicus (Rat)
Description:
Native CK2 purified from rat liver was used in enzyme phosphorylation assay.
Residue:
391
Sequence:
MSGPVPSRARVYTDVNTHRPREYWDYESHVVEWGNQDDYQLVRKLGRGKYSEVFEAINITNNEKVVVKILKPVKKKKIKREIKILENLRGGPNIITLADIVKDPVSRTPALVFEHVNNTDFKQLYQTLTDYDIRFYMYEILKALDYCHSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHPGQEYNVRVASRYFKGPELLVDYQMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLGTEDLYDYIDKYNIELDPRFNDILGRHSRKRWERFVHSENQHLVSPEALDFLDKLLRYDHQSRLTAREAMEHPYFYTVVKDQARMSSAGMAGGSTPVSSANMMSGISSVPTPSPLGPLAGSPVIAAANSLGIPVPAAAGAQQ
  
Inhibitor
Name:
BDBM34044
Synonyms:
iodinated benzimidazole, 7a
Type:
Small organic molecule
Emp. Form.:
C8H4I4N2
Mol. Mass.:
635.7486
SMILES:
Cc1nc2c(I)c(I)c(I)c(I)c2[nH]1
Structure:
Search PDB for entries with ligand similarity:
Substrate
Name:
CK-2 Peptide Substrate
Synonyms:
n/a
Type:
Peptide
Mol. Mass.:
1446.31
Organism:
n/a
Description:
n/a
Residue:
12
Sequence:
RRRADDSDDDDD