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TargetLiver X Receptor beta (LXR-beta)
LigandBDBM35106
Substrate/CompetitorBDBM19993
Meas. Tech.LXR Binding Assay and hLXR Reporter Assay
pH7.4±n/a
Temperature277.15±n/a K
IC50 2.9±n/a nM
EC50 170±n/a nM
CommentsEfficacy=85%.
Citation Bernotas, RCSinghaus, RRKaufman, DHUllrich, JFletcher, HQuinet, ENambi, PUnwalla, RWilhelmsson, AGoos-Nilsson, AFarnegardh, MWrobel, J Biarylether amide quinolines as liver X receptor agonists. Bioorg Med Chem17:1663-70 (2009) [PubMed]  Article
More Info.:Get all data from this article,   Solution Info,  Assay Method
 
Liver X Receptor beta (LXR-beta)
Name:Liver X Receptor beta (LXR-beta)
Synonyms:Nuclear orphan receptor LXR-beta | Nuclear receptor NER | Nuclear receptor subfamily 1 group H member 2 | Oxysterols receptor LXR-beta | Ubiquitously-expressed nuclear receptor
Type:Receptor
Mol. Mass.:34695.50
Organism:Homo sapiens (human)
Description:LXR beta ligand binding domain (amino acid residues 154-461) with an N-terminal biotinylation tag expressed in E.coli, was used for the binding assays.
Residue:308
Sequence:
MREQCVLSEEQIRKKKIRKQQQQESQSQSQSPVGPQGSSSSASGPGASPGGSEAGSQGSG
EGEGVQLTAAQELMIQQLVAAQLQCNKRSFSDQPKVTPWPLGADPQSRDARQQRFAHFTE
LAIISVQEIVDFAKQVPGFLQLGREDQIALLKASTIEIMLLETARRYNHETECITFLKDF
TYSKDDFHRAGLQVEFINPIFEFSRAMRRLGLDDAEYALLIAINIFSADRPNVQEPGRVE
ALQQPYVEALLSYTRIKRPQDQLRFPRMLMKLVSLRTLSSVHSEQVFALRLQDKKLPPLL
SEIWDVHE
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BDBM35106
NameBDBM35106
Synonyms:biarylether amide quinoline, 4f
TypeSmall organic molecule
Emp. Form.C35H29F3N2O2
Mol. Mass.566.6122
SMILESFC(F)(F)c1cccc2c(c(Cc3ccccc3)cnc12)-c1cccc(Oc2cccc(c2)C(=O)N2CCCCC2)c1
Structure
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BDBM19993
NameBDBM19993
Synonyms:CHEMBL62136 | N-[4-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)phenyl]-N-(2,2,2-trifluoroethyl)benzenesulfonamide | T 0901317 | T0901317 | TO-901317 | [3H]T0901317
TypeSmall organic molecule
Emp. Form.C17H12F9NO3S
Mol. Mass.481.333
SMILESOC(c1ccc(cc1)N(CC(F)(F)F)S(=O)(=O)c1ccccc1)(C(F)(F)F)C(F)(F)F
Structure
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