Ki Summary BindingDB logo
myBDB logout
Reaction Details
Report a problem with these data
TargetLiver X Receptor beta (LXR-beta)
LigandBDBM35108
Substrate/CompetitorBDBM19993
Meas. Tech.LXR Binding Assay and hLXR Reporter Assay
pH7.4±n/a
Temperature277.15±n/a K
IC50 9±n/a nM
EC50 800±n/a nM
CommentsEfficacy=66%.
Citation Bernotas, RCSinghaus, RRKaufman, DHUllrich, JFletcher, HQuinet, ENambi, PUnwalla, RWilhelmsson, AGoos-Nilsson, AFarnegardh, MWrobel, J Biarylether amide quinolines as liver X receptor agonists. Bioorg Med Chem17:1663-70 (2009) [PubMed]  Article
More Info.:Get all data from this article,   Solution Info,  Assay Method
 
Liver X Receptor beta (LXR-beta)
Name:Liver X Receptor beta (LXR-beta)
Synonyms:Nuclear orphan receptor LXR-beta | Nuclear receptor NER | Nuclear receptor subfamily 1 group H member 2 | Oxysterols receptor LXR-beta | Ubiquitously-expressed nuclear receptor
Type:Receptor
Mol. Mass.:34695.50
Organism:Homo sapiens (human)
Description:LXR beta ligand binding domain (amino acid residues 154-461) with an N-terminal biotinylation tag expressed in E.coli, was used for the binding assays.
Residue:308
Sequence:
MREQCVLSEEQIRKKKIRKQQQQESQSQSQSPVGPQGSSSSASGPGASPGGSEAGSQGSG
EGEGVQLTAAQELMIQQLVAAQLQCNKRSFSDQPKVTPWPLGADPQSRDARQQRFAHFTE
LAIISVQEIVDFAKQVPGFLQLGREDQIALLKASTIEIMLLETARRYNHETECITFLKDF
TYSKDDFHRAGLQVEFINPIFEFSRAMRRLGLDDAEYALLIAINIFSADRPNVQEPGRVE
ALQQPYVEALLSYTRIKRPQDQLRFPRMLMKLVSLRTLSSVHSEQVFALRLQDKKLPPLL
SEIWDVHE
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM35108
NameBDBM35108
Synonyms:biarylether amide quinoline, 4i
TypeSmall organic molecule
Emp. Form.C24H19ClN2O2
Mol. Mass.402.873
SMILESCNC(=O)c1cccc(Oc2cccc(c2)-c2c(C)cnc3c(Cl)cccc23)c1
Structure
Search PDB for entries with ligand similarity:Similarity to this molecule at least:
BDBM19993
NameBDBM19993
Synonyms:CHEMBL62136 | N-[4-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)phenyl]-N-(2,2,2-trifluoroethyl)benzenesulfonamide | T 0901317 | T0901317 | TO-901317 | [3H]T0901317
TypeSmall organic molecule
Emp. Form.C17H12F9NO3S
Mol. Mass.481.333
SMILESOC(c1ccc(cc1)N(CC(F)(F)F)S(=O)(=O)c1ccccc1)(C(F)(F)F)C(F)(F)F
Structure
Search PDB for entries with ligand similarity:Similarity to this molecule at least: