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TargetQuinone reductase 1)
LigandBDBM35538
Substrate/CompetitorBDBM24778
Meas. Tech.Inhibition of NQO1 (With 2 uM BSA)
pH7.5±n/a
Temperature298.15±n/a K
IC50 22333±12660 nM
Citation Nolan, KADoncaster, JRDunstan, MSScott, KAFrenkel, ADSiegel, DRoss, DBarnes, JLevy, CLeys, DWhitehead, RCStratford, IJBryce, RA Synthesis and biological evaluation of coumarin-based inhibitors of NAD(P)H: quinone oxidoreductase-1 (NQO1). J Med Chem52:7142-56 (2009) [PubMed]  Article
More Info.:Get all data from this article,  Inhibition_Run data,   Solution Info,  Assay Method
 
Quinone reductase 1)
Name:Quinone reductase 1)
Synonyms:Azoreductase | DT-diaphorase | Menadione reductase | NAD(P)H dehydrogenase [quinone] 1 | NAD(P)H:quinone oxidoreductase 1 | Phylloquinone reductase | QR1 | Quinone Reductase 1 | Quinone reductase 1)
Type:Homodimer
Mol. Mass.:30874.82
Organism:Homo sapiens (Human)
Description:n/a
Residue:274
Sequence:
MVGRRALIVLAHSERTSFNYAMKEAAAAALKKKGWEVVESDLYAMNFNPIISRKDITGKL
KDPANFQYPAESVLAYKEGHLSPDIVAEQKKLEAADLVIFQFPLQWFGVPAILKGWFERV
FIGEFAYTYAAMYDKGPFRSKKAVLSITTGGSGSMYSLQGIHGDMNVILWPIQSGILHFC
GFQVLEPQLTYSIGHTPADARIQILEGWKKRLENIWDETPLYFAPSSLFDLNFQAGFLMK
KEVQDEEKNKKFGLSVGHHLGKSIPTDNQIKARK
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BDBM35538
NameBDBM35538
Synonyms:CHEMBL81697 | symmetric dicoumarol analogue, 14
TypeSmall organic molecule
Emp. Form.C22H16O8
Mol. Mass.408.3576
SMILESCCOC(=O)C(c1c(O)c2ccccc2oc1=O)c1c(O)c2ccccc2oc1=O
Structure
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BDBM24778
NameBDBM24778
Synonyms:2-methyl-1,4-dihydronaphthalene-1,4-dione | 2-methyl-1,4-naphthoquinone, 5 | CHEMBL590 | Menadione | Menadione (5d) | Menadione (Vitamin K3) | Menadione, 9 | Vitamin K3 | cid_4055
TypeSmall organic molecule
Emp. Form.C11H8O2
Mol. Mass.172.18
SMILESCC1=CC(=O)c2ccccc2C1=O |t:1|
Structure
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