Reaction Details Report a problem with these data
Target
Sliding-clamp-loader large/small subunit
Ligand
BDBM36323
Substrate
BDBM50118233
Meas. Tech.
colorimetric ATPase assay
pH
7.5±0
Temperature
298.15±0 K
Ki
3.42e+4± 6.7e+3 nM
Citation
 Eng, K; Scouten-Ponticelli, SK; Sutton, M; Berdis, A Selective Inhibition of DNA Replicase Assembly by a Non-natural Nucleotide: Exploiting the Structural Diversity of ATP-Binding Sites ACS Chem Biol 5:183-94 (2010) [PubMed]  Article 
Target
Name:
Sliding-clamp-loader large/small subunit
Synonyms:
ATP-dependent clamp loaders gp44/62
Type:
n/a
Mol. Mass.:
n/a
Description:
n/a
Components:
This complex has 2 components.
Component 1
Name:
Sliding-clamp-loader large subunit
Synonyms:
44 | Clamp loader large subunit | Gene product 44 | LOADL_BPT4 | Sliding-clamp-loader gp44 subunit | gp44
Type:
n/a
Mol. Mass.:
35788.87
Organism:
Enterobacteria phage T4 (Bacteriophage T4)
Description:
P04526
Residue:
319
Sequence:
MITVNEKEHILEQKYRPSTIDECILPAFDKETFKSITSKGKIPHIILHSPSPGTGKTTVAKALCHDVNADMMFVNGSDCKIDFVRGPLTNFASAASFDGRQKVIVIDEFDRSGLAESQRHLRSFMEAYSSNCSIIITANNIDGIIKPLQSRCRVITFGQPTDEDKIEMMKQMIRRLTEICKHEGIAIADMKVVAALVKKNFPDFRKTIGELDSYSSKGVLDAGILSLVTNDRGAIDDVLESLKNKDVKQLRALAPKYAADYSWFVGKLAEEIYSRVTPQSIIRMYEIVGENNQYHGIAANTELHLAYLFIQLACEMQWK
  
Component 2
Name:
Sliding-clamp-loader small subunit
Synonyms:
62 | Clamp loader small subunit | Gene product 62 | LOADS_BPT4 | Sliding-clamp-loader gp44 subunit | gp62
Type:
n/a
Mol. Mass.:
21366.49
Organism:
Enterobacteria phage T4 (Bacteriophage T4)
Description:
P04527
Residue:
187
Sequence:
MSLFKDDIQLNEHQVAWYSKDWTAVQSAADSFKEKAENEFFEIIGAINNKTKCSIAQKDYSKFMVENALSQFPECMPAVYAMNLIGSGLSDEAHFNYLMAAVPRGKRYGKWAKLVEDSTEVLIIKLLAKRYQVNTNDAINYKSILTKNGKLPLVLKELKGLVTDDFLKEVTKNVKEQKQLKKLALEW
  
Inhibitor
Name:
BDBM36323
Synonyms:
4-nitro-indolyl- 2'-deoxyriboside triphosphate | d4-NITP
Type:
Small organic molecule
Emp. Form.:
C13H17N2O14P3
Mol. Mass.:
518.2004
SMILES:
[H][C@]1(O)C[C@@]([H])(O[C@]1([H])COP(O)(=O)OP(O)(=O)OP(O)(O)=O)n1ccc2c(cccc12)[N+]([O-])=O
Structure:
Search PDB for entries with ligand similarity:
Substrate
Name:
BDBM50118233
Synonyms:
2'-deoxyadenosine 5'-(tetrahydrogen triphosphate) | ATP,2'-deoxy | CHEMBL335538 | dATP
Type:
Small organic molecule
Emp. Form.:
C10H16N5O12P3
Mol. Mass.:
491.1816
SMILES:
Nc1ncnc2n(cnc12)[C@H]1C[C@H](O)[C@@H](COP(O)(=O)OP(O)(=O)OP(O)(O)=O)O1 |r|
Structure:
Search PDB for entries with ligand similarity: