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Target
Complex of Sliding-clamp-loader large subunit [R175L] and Sliding-clamp-loader small subunit
Ligand
BDBM36317
Substrate
BDBM50118233
Meas. Tech.
colorimetric ATPase assay
pH
7.5±0
Temperature
298.15±0 K
Ki
3.4e+4± 1.4e+4 nM
Citation
 Eng, K; Scouten-Ponticelli, SK; Sutton, M; Berdis, A Selective Inhibition of DNA Replicase Assembly by a Non-natural Nucleotide: Exploiting the Structural Diversity of ATP-Binding Sites ACS Chem Biol 5:183-94 (2010) [PubMed]  Article 
Target
Name:
Complex of Sliding-clamp-loader large subunit [R175L] and Sliding-clamp-loader small subunit
Synonyms:
ATP-dependent clamp loaders gp44/62 (R175L)
Type:
PROTEIN
Mol. Mass.:
57093.31
Organism:
bacteriophage T4
Description:
Modified from ATP-dependent clamp loaders 44/62
Residue:
506
Sequence:
MITVNEKEHILEQKYRPSTIDECILPAFDKETFKSITSKGKIPHIILHSPSPGTGKTTVAKALCHDVNADMMFVNGSDCKIDFVRGPLTNFASAASFDGRQKVIVIDEFDRSGLAESQRHLRSFMEAYSSNCSIIITANNIDGIIKPLQSRCRVITFGQPTDEDKIEMMKQMIRLLTEICKHEGIAIADMKVVAALVKKNFPDFRKTIGELDSYSSKGVLDAGILSLVTNDRGAIDDVLESLKNKDVKQLRALAPKYAADYSWFVGKLAEEIYSRVTPQSIIRMYEIVGENNQYHGIAANTELHLAYLFIQLACEMQWKMSLFKDDIQLNEHQVAWYSKDWTAVQSAADSFKEKAENEFFEIIGAINNKTKCSIAQKDYSKFMVENALSQFPECMPAVYAMNLIGSGLSDEAHFNYLMAAVPRGKRYGKWAKLVEDSTEVLIIKLLAKRYQVNTNDAINYKSILTKNGKLPLVLKELKGLVTDDFLKEVTKNVKEQKQLKKLALEW
  
Inhibitor
Name:
BDBM36317
Synonyms:
5-ethylene-indolyl- 2'-deoxyriboside triphosphate | 5-ethylene-indolyl- 2=-deoxyriboside triphosphate | d5-EyITP
Type:
Small organic molecule
Emp. Form.:
C15H20NO12P3
Mol. Mass.:
499.2401
SMILES:
[H][C@]1(O)C[C@@]([H])(O[C@]1([H])COP(O)(=O)OP(O)(=O)OP(O)(O)=O)n1ccc2cc(C=C)ccc12
Structure:
Search PDB for entries with ligand similarity:
Substrate
Name:
BDBM50118233
Synonyms:
2'-deoxyadenosine 5'-(tetrahydrogen triphosphate) | ATP,2'-deoxy | CHEMBL335538 | dATP
Type:
Small organic molecule
Emp. Form.:
C10H16N5O12P3
Mol. Mass.:
491.1816
SMILES:
Nc1ncnc2n(cnc12)[C@H]1C[C@H](O)[C@@H](COP(O)(=O)OP(O)(=O)OP(O)(O)=O)O1 |r|
Structure:
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