Reaction Details Report a problem with these data
Target
Kinesin-like protein KIF11 [D130V]
Ligand
BDBM36350
Substrate
n/a
Meas. Tech.
HCT116-D130V not selected
pH
6.8±0
IC50
0.45±0.0 nM
Citation
Luo, L; Parrish, CA; Nevins, N; McNulty, DE; Chaudhari, AM; Carson, JD; Sudakin, V; Shaw, AN; Lehr, R; Zhao, H; Sweitzer, S; Lad, L; Wood, KW; Sakowicz, R; Annan, RS; Huang, PS; Jackson, JR; Dhanak, D; Copeland, RA; Auger, KR ATP-competitive inhibitors of the mitotic kinesin KSP that function via an allosteric mechanism. Nat Chem Biol 3:722-6 (2007) [PubMed] Article
More Info.:
Target
Name:
Kinesin-like protein KIF11 [D130V]
Synonyms:
EG5 | KIF11 | KIF11_HUMAN | KNSL1 | KSP Mutant (D130V) | TRIP5 | kinesin spindle protein Mutant (D130V)
Type:
PROTEIN
Mol. Mass.:
119124.02
Organism:
Homo sapiens (Human)
Description:
Kinesin-like spindle protein HKSP
Residue:
1056
Sequence:
MASQPNSSAKKKEEKGKNIQVVVRCRPFNLAERKASAHSIVECDPVRKEVSVRTGGLADKSSRKTYTFDMVFGASTKQIDVYRSVVCPILDEVIMGYNCTIFAYGQTGTGKTFTMEGERSPNEEYTWEEVPLAGIIPRTLHQIFEKLTDNGTEFSVKVSLLEIYNEELFDLLNPSSDVSERLQMFDDPRNKRGVIIKGLEEITVHNKDEVYQILEKGAAKRTTAATLMNAYSSRSHSVFSVTIHMKETTIDGEELVKIGKLNLVDLAGSENIGRSGAVDKRAREAGNINQSLLTLGRVITALVERTPHVPYRESKLTRILQDSLGGRTRTSIIATISPASLNLEETLSTLEYAHRAKNILNKPEVNQKLTKKALIKEYTEEIERLKRDLAAAREKNGVYISEENFRVMSGKLTVQEEQIVELIEKIGAVEEELNRVTELFMDNKNELDQCKSDLQNKTQELETTQKHLQETKLQLVKEEYITSALESTEEKLHDAASKLLNTVEETTKDVSGLHSKLDRKKAVDQHNAEAQDIFGKNLNSLFNNMEELIKDGSSKQKAMLEVHKTLFGNLLSSSVSALDTITTVALGSLTSIPENVSTHVSQIFNMILKEQSLAAESKTVLQELINVLKTDLLSSLEMILSPTVVSILKINSQLKHIFKTSLTVADKIEDQKKELDGFLSILCNNLHELQENTICSLVESQKQCGNLTEDLKTIKQTHSQELCKLMNLWTERFCALEEKCENIQKPLSSVQENIQQKSKDIVNKMTFHSQKFCADSDGFSQELRNFNQEGTKLVEESVKHSDKLNGNLEKISQETEQRCESLNTRTVYFSEQWVSSLNEREQELHNLLEVVSQCCEASSSDITEKSDGRKAAHEKQHNIFLDQMTIDEDKLIAQNLELNETIKIGLTKLNCFLEQDLKLDIPTGTTPQRKSYLYPSTLVRTEPREHLLDQLKRKQPELLMMLNCSENNKEETIPDVDVEEAVLGQYTEEPLSQEPSVDAGVDCSSIGGVPFFQHKKSHGKDKENRGINTLERSKVEETTEHLVTKSRLPLRAQINL