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TargetSF3B3
LigandBDBM36362
Substrate/Competitorn/a
Meas. Tech.WiDr
pH7.8±0
Temperature277.15±0 K
EC50 595.0±0.0 nM
Citation Kotake, YSagane, KOwa, TMimori-Kiyosue, YShimizu, HUesugi, MIshihama, YIwata, MMizui, Y Splicing factor SF3b as a target of the antitumor natural product pladienolide. Nat Chem Biol3:570-5 (2007) [PubMed]  Article
More Info.:Get all data from this article,   Solution Info,  Assay Method
 
SF3B3
Name:SF3B3
Synonyms:SAP130
Type:PROTEIN
Mol. Mass.:135544.53
Organism:Homo sapiens (Human)
Description:Q15393
Residue:1217
Sequence:
MFLYNLTLQRATGISFAIHGNFSGTKQQEIVVSRGKILELLRPDPNTGKVHTLLTVEVFG
VIRSLMAFRLTGGTKDYIVVGSDSGRIVILEYQPSKNMFEKIHQETFGKSGCRRIVPGQF
LAVDPKGRAVMISAIEKQKLVYILNRDAAARLTISSPLEAHKANTLVYHVVGVDVGFENP
MFACLEMDYEEADNDPTGEAAANTQQTLTFYELDLGLNHVVRKYSEPLEEHGNFLITVPG
GSDGPSGVLICSENYITYKNFGDQPDIRCPIPRRRNDLDDPERGMIFVCSATHKTKSMFF
FLAQTEQGDIFKITLETDEDMVTEIRLKYFDTVPVAAAMCVLKTGFLFVASEFGNHYLYQ
IAHLGDDDEEPEFSSAMPLEEGDTFFFQPRPLKNLVLVDELDSLSPILFCQIADLANEDT
PQLYVACGRGPRSSLRVLRHGLEVSEMAVSELPGNPNAVWTVRRHIEDEFDAYIIVSFVN
ATLVLSIGETVEEVTDSGFLGTTPTLSCSLLGDDALVQVYPDGIRHIRADKRVNEWKTPG
KKTIVKCAVNQRQVVIALTGGELVYFEMDPSGQLNEYTERKEMSADVVCMSLANVPPGEQ
RSRFLAVGLVDNTVRIISLDPSDCLQPLSMQALPAQPESLCIVEMGGTEKQDELGERGSI
GFLYLNIGLQNGVLLRTVLDPVTGDLSDTRTRYLGSRPVKLFRVRMQGQEAVLAMSSRSW
LSYSYQSRFHLTPLSYETLEFASGFASEQCPEGIVAISTNTLRILALEKLGAVFNQVAFP
LQYTPRKFVIHPESNNLIIIETDHNAYTEATKAQRKQQMAEEMVEAAGEDERELAAEMAA
AFLNENLPESIFGAPKAGNGQWASVIRVMNPIQGNTLDLVQLEQNEAAFSVAVCRFSNTG
EDWYVLVGVAKDLILNPRSVAGGFVYTYKLVNNGEKLEFLHKTPVEEVPAAIAPFQGRVL
IGVGKLLRVYDLGKKKLLRKCENKHIANYISGIQTIGHRVIVSDVQESFIWVRYKRNENQ
LIIFADDTYPRWVTTASLLDYDTVAGADKFGNICVVRLPPNTNDEVDEDPTGNKALWDRG
LLNGASQKAEVIMNYHVGETVLSLQKTTLIPGGSESLVYTTLSGGIGILVPFTSHEDHDF
FQHVEMHLRSEHPPLCGRDHLSFRSYYFPVKNVIDGDLCEQFNSMEPNKQKNVSEELDRT
PPEVSKKLEDIRTRYAF
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM36362
NameBDBM36362
Synonyms:CID1620213 | Pladienolide analog 10
TypeSmall organic molecule
Emp. Form.C58H85F3N8O12S
Mol. Mass.1175.402
SMILES[H][C@@]12CS[C@H](CCCCC(=O)N(C)CCN(C)C(=O)[C@H](CCCCNC(=O)O[C@H]3\C=C\[C@H](C)[C@H](OC(=O)C[C@H](O)CC[C@@]3(C)O)C(\C)=C\C=C\[C@@H](C)C[C@H]3O[C@@H]3[C@H](C)[C@@H](O)CC)NC(=O)c3ccc(cc3)C3(N=N3)C(F)(F)F)[C@]1([H])NC(=O)N2 |c:75,t:29|
Structure
Search PDB for entries with ligand similarity:Similarity to this molecule at least:
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