Reaction Details Report a problem with these data
Target
Caspase-3
Ligand
BDBM36363
Substrate
n/a
Meas. Tech.
Procaspase-3 Activation Assay
pH
7.4±0
Temperature
310.15±0 K
EC50
2.2e+2±n/a nM
Citation
 Putt, KS; Chen, GW; Pearson, JM; Sandhorst, JS; Hoagland, MS; Kwon, JT; Hwang, SK; Jin, H; Churchwell, MI; Cho, MH; Doerge, DR; Helferich, WG; Hergenrother, PJ Small-molecule activation of procaspase-3 to caspase-3 as a personalized anticancer strategy. Nat Chem Biol 2:543-50 (2006) [PubMed]  Article 
Target
Name:
Caspase-3
Synonyms:
Apopain | CASP-3 | CASP3 | CASP3_HUMAN | CPP-32 | CPP32 | Caspase 3 | Caspase-3 subunit p12 | Caspase-3 subunit p17 | Cysteine protease CPP32 | SCA-1 | SREBP cleavage activity 1 | Yama protein | caspase-3 preproprotein
Type:
Hydrolase; heterotetramer of two heterodimers
Mol. Mass.:
31607.55
Organism:
Homo sapiens (Human)
Description:
n/a
Residue:
277
Sequence:
MENTENSVDSKSIKNLEPKIIHGSESMDSGISLDNSYKMDYPEMGLCIIINNKNFHKSTGMTSRSGTDVDAANLRETFRNLKYEVRNKNDLTREEIVELMRDVSKEDHSKRSSFVCVLLSHGEEGIIFGTNGPVDLKKITNFFRGDRCRSLTGKPKLFIIQACRGTELDCGIETDSGVDDDMACHKIPVEADFLYAYSTAPGYYSWRNSKDGSWFIQSLCAMLKQYADKLEFMHILTRVNRKVATEFESFSFDATFHAKKQIPCIVSMLTKELYFYH
  
Inhibitor
Name:
BDBM36363
Synonyms:
CID6851947 | PAC-1 | US10166229, Example PAC-1
Type:
Small organic molecule
Emp. Form.:
C23H28N4O2
Mol. Mass.:
392.494
SMILES:
Oc1c(CC=C)cccc1\C=N\NC(=O)CN1CCN(Cc2ccccc2)CC1
Structure:
Search PDB for entries with ligand similarity: