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Target
Protein Wnt-2
Ligand
BDBM50294835
Substrate
n/a
Meas. Tech.
Wnt Inhibition Assay
pH
7.4±0
Temperature
277.15±0 K
IC50
58±0.0 nM
Citation
 Chen, B; Dodge, ME; Tang, W; Lu, J; Ma, Z; Fan, CW; Wei, S; Hao, W; Kilgore, J; Williams, NS; Roth, MG; Amatruda, JF; Chen, C; Lum, L Small molecule-mediated disruption of Wnt-dependent signaling in tissue regeneration and cancer. Nat Chem Biol 5:100-7 (2009) [PubMed]  Article 
Target
Name:
Protein Wnt-2
Synonyms:
Irp | Protein Wnt | WNT2_MOUSE | Wnt-2 | Wnt2
Type:
Protein
Mol. Mass.:
40507.27
Organism:
Mus musculus (Mouse)
Description:
P21552
Residue:
360
Sequence:
MNVPLGGIWLWLPLLLTWLTPEVSSSWWYMRATGGSSRVMCDNVPGLVSRQRQLCHRHPDVMRAIGLGVAEWTAECQHQFRQHRWNCNTLDRDHSLFGRVLLRSSRESAFVYAISSAGVVFAITRACSQGELKSCSCDPKKKGSAKDSKGTFDWGGCSDNIDYGIKFARAFVDAKERKGKDARALMNLHNNRAGRKAVKRFLKQECKCHGVSGSCTLRTCWLAMADFRKTGDYLWRKYNGAIQVVMNQDGTGFTVANKRFKKPTKNDLVYFENSPDYCIRDREAGSLGTAGRVCNLTSRGMDSCEVMCCGRGYDTSHVTRMTKCECKFHWCCAVRCQDCLEALDVHTCKAPKSADWATPT
  
Inhibitor
Name:
BDBM50294835
Synonyms:
4-((1S,2S,6R,7R)-3,5-Dioxo-4-aza-tricyclo[5.2.1.0*2,6*]dec-8-en-4-yl)-N-methyl-N-quinolin-8-yl-benzamide | CHEMBL551505 | CHEMBL562310 | N-(Quinolin-8-yl)-4-(endo-4-aza-3,5-dioxotricyclo[5.2.1.02,6]oct-8-en-4-yl)benzamide, 1
Type:
Small organic molecule
Emp. Form.:
C25H19N3O3
Mol. Mass.:
409.4367
SMILES:
Oc1c2[C@H]3C[C@H](C=C3)c2c(O)n1-c1ccc(cc1)C(=O)Nc1cccc2cccnc12 |r,c:6|
Structure:
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