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Target
cAMP-dependent protein kinase
Ligand
BDBM36604
Substrate
n/a
Meas. Tech.
Inhibition Assay
pH
7.5±0
Temperature
303.15±0 K
Ki
3.5±0 nM
IC50
5.7±0.0 nM
Citation
 Koide, K; Bunnage, ME; Gomez Paloma, L; Kanter, JR; Taylor, SS; Brunton, LL; Nicolaou, KC Molecular design and biological activity of potent and selective protein kinase inhibitors related to balanol. Chem Biol 2:601-8 (1995) [PubMed]  Article 
Target
Name:
cAMP-dependent protein kinase
Synonyms:
Cyclic AMP-dependent protein kinase (PKA) | PKA catalytic subunit alpha | Serine/threonine-protein kinase | cAMP-dependent protein kinase alpha-catalytic subunit
Type:
Enzyme
Mol. Mass.:
40766.33
Organism:
Oryctolagus cuniculus (Rabbit)
Description:
Q95J97
Residue:
351
Sequence:
MGNAAAAKKGSEQESVKEFLAKAKEDFLKKWENPAQNTAQLDQFERIKTLGTGSFGRVMLSKHKETGNHYAMKILDKQKVVKLKQIEHTLNVKRILQAVNFPFLVKLEFSFKENSNLYMVMEYVPGGEMFSHLRRIGRFSEPHARFYAAQIVLTFEYLHSLDLIYRDLKPENLLIDQQGYIQQTDFGFAKRVKGRTWTLCGTPEYLAPEIILSKGYNKAVDWWALGVLIYEMAADYPPFFADQPIQIYEKIVYGKVRFPSHFSSDLKDLLRNLQQVDLTKRFGNLKNGVNDIKNHKWFATTDWIAIYQRKVEAPFIPKFKGPGDTSNFDDYEEEEIRVSINEKCGKEFSEF
  
Inhibitor
Name:
BDBM36604
Synonyms:
5'-Deoxybalanol, 7
Type:
Small organic molecule
Emp. Form.:
C28H26N2O9
Mol. Mass.:
534.514
SMILES:
OC(=O)c1cccc(O)c1C(=O)c1c(O)cc(cc1O)C(=O)O[C@@H]1CCCNC[C@H]1NC(=O)c1ccccc1 |r|
Structure:
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