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Target
Cyclin-dependent kinase 1
Ligand
BDBM36788
Substrate
n/a
Meas. Tech.
Inhibition Assay
IC50
40±0.0 nM
Citation
 Chang, YT; Gray, NS; Rosania, GR; Sutherlin, DP; Kwon, S; Norman, TC; Sarohia, R; Leost, M; Meijer, L; Schultz, PG Synthesis and application of functionally diverse 2,6,9-trisubstituted purine libraries as CDK inhibitors. Chem Biol 6:361-75 (1999) [PubMed]  Article 
Target
Name:
Cyclin-dependent kinase 1
Synonyms:
CDC2 | CDC28A | CDK1 | CDK1_HUMAN | CDKN1 | Cell division control protein 2 homolog | Cell division protein kinase 1 | Cyclin-dependent kinase 1 (CDK1) | P34CDC2 | p34 protein kinase
Type:
Enzyme Subunit
Mol. Mass.:
34101.08
Organism:
Homo sapiens (Human)
Description:
P06493
Residue:
297
Sequence:
MEDYTKIEKIGEGTYGVVYKGRHKTTGQVVAMKKIRLESEEEGVPSTAIREISLLKELRHPNIVSLQDVLMQDSRLYLIFEFLSMDLKKYLDSIPPGQYMDSSLVKSYLYQILQGIVFCHSRRVLHRDLKPQNLLIDDKGTIKLADFGLARAFGIPIRVYTHEVVTLWYRSPEVLLGSARYSTPVDIWSIGTIFAELATKKPLFHGDSEIDQLFRIFRALGTPNNEVWPEVESLQDYKNTFPKWKPGSLASHVKNLDENGLDLLSKMLIYDPAKRISGKMALNHPYFNDLDNQIKKM
  
Inhibitor
Name:
BDBM36788
Synonyms:
2-(1 R-isopropyl-2-hydroxyethylamino)-9-isopropylpurine core C6-substituent, 73
Type:
Small organic molecule
Emp. Form.:
C19H27BrN6O
Mol. Mass.:
435.361
SMILES:
CC(C)[C@H](CO)Nc1nc2N(CNc2c(Nc2ccc(Br)cc2)n1)C(C)C |r|
Structure:
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