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TargetRetinoic Acid Receptors Gamma / Alpha
LigandBDBM36811
Substrate/Competitorn/a
Meas. Tech.Competitive Assay
pH8±0
Temperature277.15±0 K
Ki 1.0±0.0 nM
Citation Géhin, MVivat, VWurtz, JMLosson, RChambon, PMoras, DGronemeyer, H Structural basis for engineering of retinoic acid receptor isotype-selective agonists and antagonists. Chem Biol6:519-29 (1999) [PubMed]  Article
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Retinoic Acid Receptors Gamma / Alpha
Name:Retinoic Acid Receptors Gamma / Alpha
Synonyms:n/a
Type:Protein
Mol. Mass.:n/a
Description:n/a
Components:This complex has 2 components.
Component 1
Name:Retinoic Acid Receptor, gamma
Synonyms:Nuclear receptor subfamily 1 group B member 3 | RAR-gamma
Type:Ligand-binding domain
Mol. Mass.:26502.27
Organism:Homo sapiens (Human)
Description:n/a
Residue:235
Sequence:
SPQLEELITKVSKAHQETFPSLCQLGKYTTNSSADHRVQLDLGLWDKFSELATKCIIKIV
EFAKRLPGFTGLSIADQITLLKAACLDILMLRICTRYTPEQDTMTFSDGLTLNRTQMHNA
GFGPLTDLVFAFAGQLLPLEMDDTETGLLSAICLICGDRMDLEEPEKVDKLQEPLLEALR
LYARRRRPSQPYMFPRMLMKITDLRGISTKGAERAITLKMEIPGPMPPLIREMLE
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Component 2
Name:Retinoic Acid Receptor, alpha
Synonyms:Nuclear receptor subfamily 1 group B member 1 | RAR-alpha
Type:Ligand-binding domain
Mol. Mass.:24746.59
Organism:Homo sapiens (Human)
Description:n/a
Residue:220
Sequence:
PALCQLGKYTTNNSSEQRVSLDIDLWDKFSELSTKCIIKTVEFAKQLPGFTTLTIADQIT
LLKAACLDILILRICTRYTPEQDTMTFSDGLTLNRTQMHNAGFGPLTDLVFAFANQLLPL
EMDDAETGLLSAICLICGDRQDLEQPDRVDMLQEPLLEALKVYVRKRRPSRPHMFPKMLM
KITDLRSISAKGAERVITLKMEIPGSMPPLIQEMLENSEG
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BDBM36811
NameBDBM36811
Synonyms:BMS614
TypeSmall organic molecule
Emp. Form.C29H24N2O3
Mol. Mass.448.5125
SMILESCC1(C)CC=C(c2cnc3ccccc3c2)c2cc(ccc12)C(=O)Nc1ccc(cc1)C(O)=O |t:4|
Structure
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n/a