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TargetHIV-1 Protease
LigandBDBM1198
Substrate/CompetitorHIV Protease Peptide Substrate
Meas. Tech.Protease Inhibition Assay
pH6.25±n/a
Temperature310.15±n/a K
Ki 1200±n/a nM
Citation Lehr, PBillich, ACharpiot, BEttmayer, PScholz, DRosenwirth, BGstach, H Inhibitors of human immunodeficiency virus type 1 protease containing 2-aminobenzyl-substituted 4-amino-3-hydroxy-5-phenylpentanoic acid: synthesis, activity, and oral bioavailability. J Med Chem39:2060-7 (1996) [PubMed]  Article
More Info.:Get all data from this article,   Solution Info,  Assay Method
 
HIV-1 Protease
Name:HIV-1 Protease
Synonyms:n/a
Type:Protein Complex
Mol. Mass.:n/a
Description:n/a
Components:This complex has 2 components.
Component 1
Name:HIV-1 Protease chain A
Synonyms:HIV-1 Protease (NY5-type sequence)
Type:Enzyme Subunit
Mol. Mass.:10822.21
Organism:Human immunodeficiency virus type 1
Description:n/a
Residue:99
Sequence:
PQITLWQRPLVTIKIGGQLKEALLDTGADDTVLEEMNLPGRWKPKMIGGIGGFIKVRQYD
QILIEICGHKAIGTVLVGPTPVNIIGRNLLTQIGCTLNF
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Component 2
Name:HIV-1 Protease chain A
Synonyms:HIV-1 Protease (NY5-type sequence)
Type:Enzyme Subunit
Mol. Mass.:10822.21
Organism:Human immunodeficiency virus type 1
Description:n/a
Residue:99
Sequence:
PQITLWQRPLVTIKIGGQLKEALLDTGADDTVLEEMNLPGRWKPKMIGGIGGFIKVRQYD
QILIEICGHKAIGTVLVGPTPVNIIGRNLLTQIGCTLNF
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BDBM1198
NameBDBM1198
Synonyms:2-Aminobenzyl-Substituted AHPPA deriv. 13 | tert-butyl N-[(2S,3R,4R)-4-(benzylcarbamoyl)-3-hydroxy-4-({[4-(2-hydroxyethoxy)phenyl]methyl}amino)-1-phenylbutan-2-yl]carbamate
TypeSmall organic molecule
Emp. Form.C32H41N3O6
Mol. Mass.563.6844
SMILESCC(C)(C)OC(=O)N[C@@H](Cc1ccccc1)[C@@H](O)[C@@H](NCc1ccc(OCCO)cc1)C(=O)NCc1ccccc1 |r|
Structure
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HIV Protease Peptide Substrate
Name:HIV Protease Peptide Substrate
Synonyms:n/a
Type:Peptide
Mol. Mass.:3062.94
Organism:Synthesized
Description:n/a
Residue:29
Sequence:
H-Lys-Ala-Arg-Val-Leu-pNph-Glu-Ala-Nle-NH2
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