Reaction Details Report a problem with these data
Target
Phosphorylase b kinase gamma catalytic chain, skeletal muscle/heart isoform
Ligand
BDBM5447
Substrate
n/a
Meas. Tech.
Kinase Inhibitor Selectivity Profiling Assay
Kd
3700±n/a nM
Citation
 PubChem, PC Kinase Inhibitor Selectivity Profiling Assay PubChem Bioassay (2008)[AID] 
Target
Name:
Phosphorylase b kinase gamma catalytic chain, skeletal muscle/heart isoform
Synonyms:
PHKG | PHKG1 | PHKG1_HUMAN | Phosphorylase b kinase gamma catalytic chain, skeletal muscle isoform | Phosphorylase kinase | Phosphorylase kinase gamma subunit 1 | Phosphorylase kinase subunit gamma 1
Type:
PROTEIN
Mol. Mass.:
45025.22
Organism:
Homo sapiens (Human)
Description:
ChEMBL_774515
Residue:
387
Sequence:
MTRDEALPDSHSAQDFYENYEPKEILGRGVSSVVRRCIHKPTSQEYAVKVIDVTGGGSFSPEEVRELREATLKEVDILRKVSGHPNIIQLKDTYETNTFFFLVFDLMKRGELFDYLTEKVTLSEKETRKIMRALLEVICTLHKLNIVHRDLKPENILLDDNMNIKLTDFGFSCQLEPGERLREVCGTPSYLAPEIIECSMNEDHPGYGKEVDMWSTGVIMYTLLAGSPPFWHRKQMLMLRMIMSGNYQFGSPEWDDYSDTVKDLVSRFLVVQPQNRYTAEEALAHPFFQQYLVEEVRHFSPRGKFKVIALTVLASVRIYYQYRRVKPVTREIVIRDPYALRPLRRLIDAYAFRIYGHWVKKGQQQNRAALFENTPKAVLLSLAEEDY
  
Inhibitor
Name:
BDBM5447
Synonyms:
CHEMBL939 | GEFITINIB | Iressa | N-(3-Chloro-4-fluorophenyl)-7-methoxy-6-[3-(4-morpholinyl)propoxy]-4-quinazolinamine | N-(3-chloro-4-fluorophenyl)-7-methoxy-6-[3-(morpholin-4-yl)propoxy]quinazolin-4-amine | US10106508, Gefitinib | US10507209, Compound Gefitinib | US9416123, Gefitinib | US9730934, Gefitinib | US9783524, Gefitinib | WO2022090481, Example gefitinib | ZD1839 | cid_123631
Type:
Small organic molecule
Emp. Form.:
C22H24ClFN4O3
Mol. Mass.:
446.902
SMILES:
COc1cc2ncnc(Nc3ccc(F)c(Cl)c3)c2cc1OCCCN1CCOCC1
Structure:
Search PDB for entries with ligand similarity: