Reaction Details Report a problem with these data
Target
Diphosphomevalonate decarboxylase
Ligand
BDBM38340
Substrate
n/a
Meas. Tech.
Screening for Inhibitors of the Mevalonate Pathway in Streptococcus Pneumoniae - DPM-DC Dose Response
IC50
117902.8±n/a nM
Citation
 PubChem, PC Screening for Inhibitors of the Mevalonate Pathway in Streptococcus Pneumoniae - DPM-DC Dose Response PubChem Bioassay (2007)[AID] 
Target
Name:
Diphosphomevalonate decarboxylase
Synonyms:
n/a
Type:
Enzyme Catalytic Domain
Mol. Mass.:
35571.44
Organism:
Streptococcus pneumoniae D39
Description:
A0A0H2ZN59
Residue:
317
Sequence:
MDREPVTVRSYANIAIIKYWGKKKEKEMVPATSSISLTLENMYTETTLSPLPANVTADEFYINGQLQNEVEHAKMSKIIDRYRPAGEGFVRIDTQNNMPTAAGLSSSSSGLSALVKACNAYFKLGLDRSQLAQEAKFASGSSSRSFYGPLGAWDKDSGEIYPVETDLKLAMIMLVLEDKKKPISSRDGMKLCVETSTTFDDWVRQSEKDYQDMLIYLKENDFAKIGELTEKNALAMHATTKTASPAFSYLTDASYEAMDFVRQLREKGEACYFTMDAGPNVKVFCQEKDLEHLSEIFGQRYRLIVSKTKDLSQDDCC
  
Inhibitor
Name:
BDBM38340
Synonyms:
MLS000082296 | N-(3-cyano-1-isobutyl-5-keto-10-methyl-dipyrido[3,4-c:1',2'-f]pyrimidin-2-ylidene)-piperonylamide | N-[3-cyano-10-methyl-1-(2-methylpropyl)-5-oxidanylidene-dipyrido[3,4-c:1',2'-f]pyrimidin-2-ylidene]-1,3-benzodioxole-5-carboxamide | N-[3-cyano-10-methyl-1-(2-methylpropyl)-5-oxo-2-dipyrido[3,4-c:1',2'-f]pyrimidinylidene]-1,3-benzodioxole-5-carboxamide | N-[3-cyano-10-methyl-1-(2-methylpropyl)-5-oxodipyrido[3,4-c:1',2'-f]pyrimidin-2-ylidene]-1,3-benzodioxole-5-carboxamide | SMR000046977 | cid_665853
Type:
Small organic molecule
Emp. Form.:
C25H21N5O4
Mol. Mass.:
455.4653
SMILES:
CC(C)Cn1c2nc3c(C)cccn3c(=O)c2cc(C#N)\c1=N/C(=O)c1ccc2OCOc2c1
Structure:
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