Reaction Details Report a problem with these data
Target
Isoform 2 of Nuclear receptor ROR-alpha (Alpha-2)
Ligand
BDBM39444
Substrate
n/a
Meas. Tech.
Counterscreen for activators of the nuclear receptor Steroidogenic Factor 1 (SF-1): A cell-based dose-response assay for inhibition of the RAR-related orphan receptor A (RORA)
EC50
749±n/a nM
Citation
 PubChem, PC Counterscreen for activators of the nuclear receptor Steroidogenic Factor 1 (SF-1): A cell-based dose-response assay for inhibition of the RAR-related orphan receptor A (RORA) PubChem Bioassay (2007)[AID] 
Target
Name:
Isoform 2 of Nuclear receptor ROR-alpha (Alpha-2)
Synonyms:
NR1F1 | Nuclear receptor ROR-alpha | Nuclear receptor ROR-alpha (Alpha-2) | Nuclear receptor ROR-alpha (Retinoid-related orphan receptor-alpha) (Nuclear receptor RZR-alpha). | RORA | RORA_HUMAN | RZRA
Type:
PROTEIN
Mol. Mass.:
63033.59
Organism:
Homo sapiens (Human)
Description:
EBI_101591
Residue:
556
Sequence:
MNEGAPGDSDLETEARVPWSIMGHCLRTGQARMSATPTPAGEGARRDELFGILQILHQCILSSGDAFVLTGVCCSWRQNGKPPYSQKEDKEVQTGYMNAQIEIIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQSNATYSCPRQKNCLIDRTSRNRCQHCRLQKCLAVGMSRDAVKFGRMSKKQRDSLYAEVQKHRMQQQQRDHQQQPGEAEPLTPTYNISANGLTELHDDLSNYIDGHTPEGSKADSAVSSFYLDIQPSPDQSGLDINGIKPEPICDYTPASGFFPYCSFTNGETSPTVSMAELEHLAQNISKSHLETCQYLREELQQITWQTFLQEEIENYQNKQREVMWQLCAIKITEAIQYVVEFAKRIDGFMELCQNDQIVLLKAGSLEVVFIRMCRAFDSQNNTVYFDGKYASPDVFKSLGCEDFISFVFEFGKSLCSMHLTEDEIALFSAFVLMSADRSWLQEKVKIEKLQQKIQLALQHVLQKNHREDGILTKLICKVSTLRALCGRHTEKLMAFKAIYPDIVRLHFPPLYKELFTSEFEPAMQIDG
  
Inhibitor
Name:
BDBM39444
Synonyms:
(E)-1-(3,4-dimethoxyphenyl)-3-[(6-methyl-2-pyridinyl)amino]-2-propen-1-one | (E)-1-(3,4-dimethoxyphenyl)-3-[(6-methyl-2-pyridyl)amino]prop-2-en-1-one | (E)-1-(3,4-dimethoxyphenyl)-3-[(6-methylpyridin-2-yl)amino]prop-2-en-1-one | MLS000037304 | SMR000040940 | cid_1927286
Type:
Small organic molecule
Emp. Form.:
C17H18N2O3
Mol. Mass.:
298.3364
SMILES:
COc1ccc(cc1OC)C(=O)CC=Nc1cccc(C)n1 |w:14.15|
Structure:
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