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Target
Lysosomal acid glucosylceramidase
Ligand
BDBM42362
Substrate
n/a
Meas. Tech.
Dose response cell-based high throughput screening assay to identify enhancers of beta-glucosidase activity
EC50
>10000±n/a nM
Citation
 PubChem, PC Dose response cell-based high throughput screening assay to identify enhancers of beta-glucosidase activity PubChem Bioassay (2008)[AID] 
Target
Name:
Lysosomal acid glucosylceramidase
Synonyms:
Acid beta-glucosidase | Alglucerase | Beta-glucocerebrosidase | Beta-glucocerebrosidase (GC) | D-glucosyl-N-acylsphingosine glucohydrolase | GBA | GBA1 | GBA1_HUMAN | GC | GCase | GLUC | Glucocerebrosidase (GBA) | Glucosylceramidase (GBA) | Glucosylceramidase (GCase) | Glucosylceramidase precursor (Beta-glucocerebrosidase) (Acid beta-glucosidase) (D-glucosyl-N-acylsphingosine glucohydrolase) (Alglucerase) (Imiglucerase) | Imiglucerase | beta-glucocerebrosidase (GCase)
Type:
Enzyme
Mol. Mass.:
59724.64
Organism:
Homo sapiens (Human)
Description:
The beta-Glu activity was measured with commercially available beta-glucocerebrosidase (Ceredase) as the enzyme source.
Residue:
536
Sequence:
MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ
  
Inhibitor
Name:
BDBM42362
Synonyms:
MLS000094696 | N-butyl-5-(6,7-diethoxy-2,4-diketo-1H-quinazolin-3-yl)-N-methyl-valeramide | N-butyl-5-(6,7-diethoxy-2,4-dioxo-1,4-dihydroquinazolin-3(2H)-yl)-N-methylpentanamide | N-butyl-5-(6,7-diethoxy-2,4-dioxo-1H-quinazolin-3-yl)-N-methylpentanamide | N-butyl-5-[6,7-diethoxy-2,4-bis(oxidanylidene)-1H-quinazolin-3-yl]-N-methyl-pentanamide | SMR000030249 | cid_3243769
Type:
Small organic molecule
Emp. Form.:
C22H33N3O5
Mol. Mass.:
419.5145
SMILES:
CCCCN(C)C(=O)CCCCn1c(=O)[nH]c2cc(OCC)c(OCC)cc2c1=O
Structure:
Search PDB for entries with ligand similarity: